6-alpha-Methylprednisolone 甲基泼尼松龙

CAS 83-43-2 MFCD00010591

化学结构图

83-43-2
SMILES: CC1CC2C(C(O)CC3(C)C2CCC3(O)C(=O)CO)C2(C)C=CC(=O)C=C12

化学属性

Mol. FormulaC22H30O5
Mol. Weight374.47
Melting Point228-237 ºC (DEC.)
Solubilitychloroform/methanol (9:1): 50 mg/mL, clear, faintly yellow
Refractive index82 ° (C=1, Dioxane)
Stability对光敏感

别名和识别编码

Chemical Name6-alpha-Methylprednisolone
CAS Number83-43-2
Synonym (6?,11?)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione (6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione 1,4-PREGNADIEN-6-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 11β,17α,21-三羟基-6α-甲基-1,4-孕甾二烯-3,20-二酮 11,17,21-trihydroxy-6-methyl-1,4-pregnadiene-3,20-dione 11BETA,17ALPHA,21-TRIHYDROXY-6ALPHA-METHYL-1,4-PREGNADIENE-3,20-DIONE 11b,17a,21-Trihydroxy-6a-methyl-1,4-pregnene-3,20-dione; 6alpha-Methyl-1,4-pregnadiene-11beta,17alpha,21-tr 11b,17a,21-trihydroxy-6 11b,17a,21-trihydroxy-6a-meth 11b,17a,21-trihydroxy-6a-methyl-1,4-pregnene-3,20-d 11β,17α,21-三羟基-6α-甲基-1,4-孕甾二烯-3, 6 Methylprednisolone 6-ALFA-METHYLPREDNISOL 6-ALPHA-METHYL-11 6-Methylprednisolone 6A-Methylprednisolon 6α-甲基-11β,17α,21-三羟基-1,4-孕甾二烯-3,20-二酮 {Chemicalboo
MDL NumberMFCD00010591
PubChem Substance ID6741
Beilstein Registry Number2340300
EC Number201-476-4
Chemical Name Translation甲基泼尼松龙
Merck Number6111
Wiswesser Line NotationL E5 B666 OV AHTTT&J A1 CQ E1 FV1Q FQ L1
LabNetwork Molecule IDLN00366059
InChIInChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
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分类

  • Alphabetic, Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Chromatography,
  • {uni_hamburg} no charge; carbocycle; alicycle; large ring; fused rings; 5ring; 6ring; 9ring; 10ring; 1
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Application Areas and Market Segments,
  • {SNA} Bioactive Small Molecule Alphabetical Index, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, M, Steroid Hormones, Steroids (C21) and Derivatives, Sterol Lipids, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 脂类

产品应用

  • 校准仪器和装置;评价方法;工作标准;质量保证/质量控制

相关文献及参考

  • [2]. Bracken, M.B., et al., A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med, 1990. 322(20): p. 1405-11.
  • [3]. Zhen Xiang, et al. Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. Int J Biol Sci 2020; 16(13):2382-2391.
  • Beil. 8 ,IV,3498
  • Bracken, M.B., et al.: J. Neurosurg., 89, 699 (1998),
  • Hall, E.D., et al.: J. Neurosurg., 76, 13 (1992),
  • Hommes, O.R., et al.: Mult. Scler., 1, 327 (1996),
  • Merck 14 ,6111
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
  • Short: II/27C Title: Diamagnetic Susc

安全信息

RTECSTU4146000
WGK Germany2
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Storage condition 0-6°C
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2292 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,832,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 20 mg/kg/45M-C
TOXIC EFFECTS :
   Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
   JRHUA9 Journal of Rheumatology.  (920 Yonge St., Suite 608, Toronto, Ont.,
   Canada)  V.1-    1974-  Volume(issue)/page/year: 13,477,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2400 ug/kg
TOXIC EFFECTS :
   Cardiac - change in rate
   Lungs, Thorax, or Respiration - respiratory depression
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   BJANAD British Journal of Anesthesia.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1923-  Volume(issue)/page/year:
   69,422,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,832,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 60 mg/kg

Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312
  • P302+P352
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

其他信息

  • Sigma Aldrich:83-43-2(sigmaaldrich)
  • 下游产品:甲基泼尼松龙乙丙酸酯
  • 图谱信息:甲基强的松龙(83-43-2)红外图谱(IR2) 甲基强的松龙(83-43-2)红外图谱(IR1) 甲基强的松龙(83-43-2)质谱(MS)
  • 用途一:适用于风湿性关节炎、胶原病、过敏性疾病、眼科疾患、淋巴白血病、软组织炎症及溶血性贫血等。
  • F:8-10-23
  • MOL 文件:83-43-2.mol

系列性分类


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