3-(Chloromethyl)pyridine hydrochloride 3-(氯甲基)吡啶盐酸盐

CAS 6959-48-4 MFCD00012818

化学结构图

6959-48-4
SMILES: Cl.ClCC1CCCNC1

化学属性

Mol. FormulaC6
Mol. Weight164
Melting Point137-143
Density1.422
TSCANo
Solubility>=10 G/100 ML AT 19 ºC

别名和识别编码

Chemical Name3-(Chloromethyl)pyridine hydrochloride
CAS Number6959-48-4
Alfabeta NameCHLOROMETHYLPYRIDINEHYDROCHLORIDE 3()-
MDL NumberMFCD00012818
EC Number230-150-4
Beilstein Registry Number3689156
Synonym 3-(Chloromethyl)PyridineHydrochloride98% 3-(Chloromethyl)pyridine hydrochloride; 3-(Chloromethyl)pyridinium chloride 3-(chloromethyl)-pyridinhydrochloride 3-CHLOROMETHYLPYRIDINEHYPOCHLORIDE 3-Picolyl chloride hydrochloride 3-Picolylchlorid Hydrochlorid NCI-C03838
PubChem Substance ID87565890
Reaxys-RN3689156
Chemical Name Translation3-(氯甲基)吡啶盐酸盐
Wiswesser Line NotationT6NJ C1G &GH
LabNetwork Molecule IDLN00009967
InChIInChI=1S/C6H6ClN.ClH/c7-4-6-2-1-3-8-5-6;/h1-3,5H,4H2;1H
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分类

  • {SNA} Building Blocks, C6, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines

相关文献及参考

  • The free base can be lithiated at the methylene group by treatment with LDA in THF at -78o. The resulting (3-pyridinylchloromethyl)lithium can be trapped by reaction with various electrophiles at low temperatures: J. Org. Chem., 61, 4148 (1996).

安全信息

Warnings HYGROSCOPIC, CORROSIVE
Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S24 Avoid contact with skin 避免皮肤接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P234 Keep only in original container. 只保留在原来的容器中。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331
  • P301+P330+P331+P310
  • P303+P361+P353+P310+P363
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P390 Absorb spillage to prevent material damage. 吸收溢出物,防止重大损害。
  • P405 Store locked up. 上锁保管。
  • P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H290 May be corrosive to metals 可能腐蚀金属。
  • H302 Harmful if swallowed 吞食有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSUS7000000
Packing GroupIII
UN Number 3261
Storage condition Store at RT. Hygroscopic
Hazard Codes 8 C Xn
Hazard Class8
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 37 gm/kg/83W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-95,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 49 gm/kg/81W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-95,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 316 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to
   the National Cancer Institute by Litton Bionetics, Inc.  (Bethesda, MD)
   Volume(issue)/page/year: NCI-E-C-72-3252,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 316 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to
   the National Cancer Institute by Litton Bionetics, Inc.  (Bethesda, MD)
   Volume(issue)/page/year: NCI-E-C-72-3252,1973

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 640 ng/plate
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 1,190,1981

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 20 ppm
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   23,208,1994

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 33300 ng/plate
REFERENCE :
   ENMUDM Environment

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 5 mg/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 9,143,1987

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 76200 nmol/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   19,98,1992

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 13100 ug/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   12(Suppl 13),37,1988

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其他信息

  • MSDS 信息:3-Picolyl chloride hydrochloride(6959-48-4).msds
  • 类别:有毒物质
  • 灭火剂:水, 二氧化碳, 干粉, 砂土
  • 毒性分级:高毒
  • F:3-10
  • 下游产品:3-(2-氨基乙基)吡啶 --> N-甲基-N-(3-甲基吡啶)胺 --> 1-[(3-吡啶)甲基]哌嗪 --> 3-吡啶乙酸
  • TCI Shanghai:3-(氯甲基)吡啶盐酸盐 3-(Chloromethyl)pyridine Hydrochloride,>;98.0%(T)(6959-48-4)
  • Alfa Aesar:3-氯甲基吡啶盐酸,97% 3-(Chloromethyl)pyridine hydrochloride, 97%(6959-48-4)
  • 可燃性危险特性:可燃, 燃烧时分解有毒氯化物, 氮氧化物气体
  • Acros Organics:3-氯甲基吡啶盐酸盐 3-Picolyl chloride hydrochloride, 99%(6959-48-4)
  • 储运特性:库房低温, 通风, 干燥 ; 防火; 与氧化剂, 食品原料分开存放
  • 急性毒性:口服- 大鼠 LD50: 316 毫克/ 公斤; 口服- 小鼠 LD50: 316 毫克/ 公斤
  • 检测方法:HPLC
  • Hazard Note:Corrosive
  • 敏感性:Hygroscopic
  • 海关编码:29333999
  • 3-氯甲基吡啶盐酸盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C0825 3-(氯甲基)吡啶盐酸盐 3-(Chloromethyl)pyridine Hydrochloride 100G 1820元 2014/06/02 C0825 3-(氯甲基)吡啶盐酸盐 3-(Chloromethyl)pyridine Hydrochloride 25G 636元 2010/06/21 131190250 3-氯甲基吡啶盐酸盐 3-Picolyl chloride hydrochloride 99% 25 GR 742元
  • MOL 文件:6959-48-4.mol
  • 用途一:用作医药中间体
  • 图谱信息:3-氯甲基吡啶盐酸盐(6959-48-4)核磁图( 13 CNMR) 3-氯甲基吡啶盐酸盐(6959-48-4)质谱(MS) 3-氯甲基吡啶盐酸盐(6959-48-4)核磁图( 1 HNMR)

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