5-Hydroxy-3-(4-Hydroxyphenyl)-7-Methoxy-4H-Chromen-4-One 5-羟基-3-(4-羟基苯基)-7-甲氧基-4H-苯并吡喃-4-酮

CAS 552-59-0 MFCD00016951

化学结构图

552-59-0
SMILES: COc1cc(O)c2c(=O)c(-c3ccc(O)cc3)coc2c1

化学属性

Mol. FormulaC₁₆H₁₂O₅
Mol. Weight284.26
Melting Point240-242°C
Boiling Point-
Flash Point-

别名和识别编码

Chemical Name5-Hydroxy-3-(4-Hydroxyphenyl)-7-Methoxy-4H-Chromen-4-One
MDL Number-
CAS Number552-59-0
Synonym 3-(p-Hydroxyphenyl)-5-hydroxy-7-methoxychromone 4′,5-Dihydroxy-7-methoxyisoflavone 4',5-DIHYDROXY-7-METHOXYISOFLAVONE 4',5-Dihydroxy-7-methoxyisoflavone 4,5-Dihydroxy-7-methoxyisoflavone 4’,5-dihydroxy-7-methoxy-isoflavon 4′,5-Dihydroxy-7-methoxyisoflavone 5,4'-DIHYDROXY-7-METHOXYISOFLAVONE 5,4'-Dihydroxy-7-methoxyisoflavone; 5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one; 5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4-benzopyrone 5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one 5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4-benzopyrone 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4h-1-benzopyran-4-on 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4h-1-benzopyran-4-one P PRUNETIN PRUNETIN(RG) Prunetin
PubChem Substance ID24887970
Beilstein Registry Number292155
EC Number209-018-5
Chemical Name Translation5-羟基-3-(4-羟基苯基)-7-甲氧基-4H-苯并吡喃-4-酮
LabNetwork Molecule IDLN01359859
Canonical SMILES-
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分类

  • {SNA} Chemical Class, Analytical Standards, Analytical/Chromatography, Phenols
  • {SNA} Analytical Standards, Chemical Class, Phenols, 分析/色谱
  • {SA} Analytical Standards, Analytical/Chromatography, Chemical Class, Phenols
  • {SNA} Additional Standards, Analytical Standards, Chemical Class, Phenols, 分析/色谱

相关文献及参考

  • [2]. Sheikh S, et al. Allosteric inhibition of human liver aldehyde dehydrogenase by the isoflavone prunetin. Biochem Pharmacol. 1997 Feb 21;53(4):471-8.
  • [1]. Hu H, et al. Prunetin inhibits lipopolysaccharide-induced inflammatory cytokine production and MUC5AC expression by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells. Biomed Pharmacother. 2018 Oct;106:1469-1477.
  • [1]. Hu H, et al. Prunetin inhibits lipopolysaccharide-induced inflammatory cytokine production and MUC5AC expression by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells. Biomed Pharmacother. 2018 Oct;106:1469-1477.
  • [2]. Sheikh S, et al. Allosteric inhibition of human liver aldehyde dehydrogenase by the isoflavone prunetin. Biochem Pharmacol. 1997 Feb 21;53(4):471-8.

安全信息

WGK Germany3
RTECSDJ3100050
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 13,51,1979

GHS Symbol
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。

其他信息

  • Sigma Aldrich:552-59-0(sigmaaldrich)
  • MOL 文件:552-59-0.mol
  • F:10
  • MSDS 信息:5,4'-Dihydroxy-7-methoxyisoflavone(552-59-0).msds

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Phenols - Chemical Class
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Food & Beverage Standards - Chromatography
  5. Food Residue Analysis - Food & Beverage Standards
  1. Medical Research Areas
  2. Metabolism
  3. Aldehyde Dehydrogenase (ALDH)  (乙醛脱氢酶)

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