Amentoflavone 穗花杉双黄酮

CAS 1617-53-4 MFCD00017470

化学结构图

1617-53-4
SMILES: O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12

化学属性

Mol. FormulaC30 H18 O10
Mol. Weight538.46
Melting Point>300°C
Boiling Point
Flash Point-
Density

别名和识别编码

Chemical NameAmentoflavone
Synonym 4',5,7-Trihydroxy-8-[2-hydroxy-5-(4-oxo-5,7-dihydroxy-4H-1-benzopyran-2-yl)phenyl]flavone 5,7,4',5'',7'',4'''-Hexahydroxy-3',8''-biflavone AMENTOFLAVONE AMENTOFLAVONE WITH HPLC AMENTOFLAVONE hplc Amentoflavone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} amentoflavone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} amentoflavone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00017470
Beilstein Registry Number380244
CAS Number1617-53-4
PubChem Substance ID5281600
Chemical Name Translation穗花杉双黄酮
Reaxys-RN380244
LabNetwork Molecule IDLN01263901
InChIInChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H
Canonical SMILESOc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)c(c3O2)c4cc(ccc4O)C5=CC(=O)c6c(O)cc(O)cc6O5
EC Number
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分类

  • {SNA} A - D, Alphabetical,
  • {SNA} A-AM, Bioactive Small Molecules, Ginkgo biloba, Hematology and Histology, Hypericum perforatum (St John's wort), Natural Dyes, Nutrition Research, Phytochemicals by Plant (Food/Spice/Herb), Stains and Dyes, 细胞生物学
  • {SNA} Ginkgo biloba, Hypericum perforatum (St John's wort), Natural Dyes, Phytochemicals by Plant (Food/Spice/Herb), Stains and Dyes, 细胞生物学, 营养研究, 血液学和组织学
  • {SNA} A - D, Alphabetical, Analytical Standards, Chromatography, Flavonoids, Garcinia, Ginkgo,

产品应用

  • Biflavonoid with anti-inflammatory, anti-viral and cancer chemopreventive activity. It inhibits vascularization of tumors by blocking the activity of angiogenic VEGFs. Blocks the induction of COX-2 and up-regulates PPAR-γ. It is a negative modulator of the GABAA receptor at the benzodiazepine binding site.

相关文献及参考

  • [2]. Xu P, et al. Amentoflavone acts as a radioprotector for irradiated v79 cells by regulating reactive oxygen species (ROS), cell cycle and mitochondrial mass. Asian Pac J Cancer Prev. 2014;15(18):7521-6.
  • [3]. Yang Y, et al. [Amentoflavone induces apoptosis in SW480 human colorectal cancer cells via regulating β-catenin and caspase-3 expressions]. Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jun;34(7):1035-8.
  • 1. Tarallo, V., et al., The biflavonoid amentoflavone inhibits neovascularization preventing the activity of proangiogenic vascular endothelial growth factors J. Biol. Chem. 286 , 19641-19651, (2011) 摘要
  • Banerjee, T., et al., Inhibition of TNFα-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF-κB activation in A549 cells. Mol. Cell Biochem. 238 , 105-110, (2002) 摘要
  • Baureithel, K.H., et al., Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum . Ph

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition +4°C 0-10 0-10°C 2-8°C 4 4°C 4℃ 贮存温度 2-8°C
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
GHS Symbol
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
UN Number
Hazard Codes
Signal word
Risk Statements
RTECS
Packing Group

其他信息

  • Sigma Aldrich:1617-53-4(sigmaaldrich)
  • MOL 文件:1617-53-4.mol
  • F:10

系列性分类

  1. Life Science 生命科学
  2. Hematology and Histology 血液学和组织学
  3. Stains and Dyes - Hematology and Histology
  4. Natural Dyes - Stains and Dyes
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. A-AM - Bioactive Small Molecules
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Phytopharma Standards - Life Sciences Standards
  6. Alphabetical - Phytopharma Standards
  7. A - D - Alphabetical
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Phytopharma Standards - Life Sciences Standards
  6. Substance Classification - Phytopharma Standards
  7. Flavonoids - Substance Classification
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Biochemicals and Reagents
  4. Stains and Dyes
  5. Natural Dyes
  1. Medical Research Areas
  2. Metabolism
  3. Reactive Oxygen Species  (活性氧)

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