L-2-Hydroxyglutaric acid (disodium) L-α-羟基戊二酸二钠盐
CAS 63512-50-5 MFCD00021700
化学结构图
SMILES: [Na+].[Na+].[O-]C(=O)CC[C@H](O)C([O-])=O
化学属性
| Mol. Formula | C5H6Na2O5 |
|---|---|
| Mol. Weight | 192 |
别名和识别编码
| Chemical Name | L-2-Hydroxyglutaric acid (disodium) |
|---|---|
| CAS Number | 63512-50-5 |
| Synonym | (2S)-2-Hydroxypentanedioic Acid (S)-2-Hydroxypentanedioic acid disodium salt (S)-2-Hydroxypentanedioic acid disodium salt Disodium (S)-2-hydroxyglutarate (S)-?-Hydroxyglutaric Acid Disodium Salt Disodium (S)-2-hydroxyglutarate L-2-Hydroxyglutarate Disodium Salt L-2-Hydroxyglutaric Acid Disodium Salt |
| Beilstein Registry Number | 5318042 |
| MDL Number | MFCD00021700 |
| PubChem Substance ID | 329769949 |
| Chemical Name Translation | L-α-羟基戊二酸二钠盐 |
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分类
- {SNA} Dicarboxylic Acids, Fatty Acids and conjugates, Fatty Acyls, 异柠檬酸脱氢酶（IDH）底物和反应产物, 生化试剂, 癌症代谢, 癌症代谢中的异柠檬酸脱氢酶（IDH）, 癌症研究, 细胞生物学, 脂类
- Biochemicals and Reagents, Cancer Metabolism, Cancer Research,
产品应用
- A potential inhibitor of glutamate carboxypeptidase.
相关文献及参考
- [2]. da Silva CG, et al. L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats. Int J Dev Neurosci. 2003 Jun;21(4):217-24.
- Frezza, C., et al., IDH1 mutations in gliomas: when an enzyme loses its grip. Cancer Cell 1st ed., 17 , 7-9, (2010)
- Knowles, P.F., et al.: Eur. J. Biochem., 114, 139 (1981),
- Wolcott, T.G., et al.: Biochem. Biophys. Res. Commun., 57, 709 (1974),
- Xu, W., et al., Oncometabolite 2-Hydroxyglutarate is a competitive inhibitor of a-ketoglutarate-dependent dioxygenases. Cancer Cell 1st ed., 19 , 17-30, (2011)
- [1]. Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4(11):1290-8.
- [1]. Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4(11):1290-8.
- [2]. da Silva CG, et al. L-2-hydroxyglutaric acid inhib
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