Diazinon 二嗪农
CAS 333-41-5 MFCD00036204
化学结构图
SMILES: CCOP(=S)(OCC)Oc1cc(C)nc(C(C)C)n1
化学属性
| Mol. Formula | C12H21N2O3PS |
|---|---|
| Mol. Weight | 304.38 |
| Melting Point | >120 ºC (DEC.) |
| Boiling Point | 85-90°C |
| Density | 1.0 |
| Solubility | 略溶于水. 0.004 G/100 ML |
| Flash Point | 104.4 °C |
| Refractive index | 1.498 |
| Stability | 对光敏感 |
别名和识别编码
| Chemical Name | Diazinon |
|---|---|
| CAS Number | 333-41-5 |
| Synonym | O,O-Diethyl O-(2-isopropyl-4-methyl-6-pyrimidyl) thionophosphate O,O-Diethyl-O-(2-isopropyl-4-methyl-6-pyrimidinyl)-phosphorothioate 二嗪农原油 Exodin {Chem 2-iso-Propyl-6-methyl-4-pyrimidylphosphorot Cooper's Flystrike Powder Nucidol O,O-Diaethyl-O-(2-isopropyl-4-methyl)-6-pyrimidyl-thionophosphat Dimpylate Phosphorothioic acid, O,O-diethyl 2-isopropyl-6-methyl-4-pyrimidinyl ester Compass (insecticide) Knox Out 2FM DIANON {hazard_ Bassadinon G-24480 Diazinon AG 500 Dizictol {Chemi O,O-Diethyl O-(6-methyl-2-(1-methylethyl)-4-pyrimidinyl) phosophorothioate O,O-diethyl O-(2 O,O-Diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) ph Dimpylat O,O-二乙基-O-(2-异丙基-4-甲基嘧啶-6-基)硫代磷酸酯 {Ch 二嗪磷 敌匹硫磷 {uni_ha O,O-DIETHYL-O-[2-ISOPROPYL-4-METHYL-6-PYRIMIDYL]PHOSPHOROTHIOATE 二嗪农 diazinon Phosphorothioate, O,O-diethyl O-6-(2-isopropyl-4-methylpyrimidyl) Antigal Phosphorothioic acid, O,O-diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) ester Dazzel {uni_hambu O,O-Diaethyl-O-(2-isopropyl-4-methyl-pyrimidin-6 Basudin 10G O,O-Diethyl O-(2-isopropyl- Basudin S 二嗪磷颗粒剂 Dizinil {u Diethyl 4-(2-isopropyl-6-methylpyrimidinyl)phosphorothionate {C OMS 469 O,O-Diaethyl-O-( Geigy 24480 O,O-二乙基-O-(2-异丙基-6-甲基-4-嘧啶基)硫逐磷酸酯 2-iso-Propyl-6-methyl-4-pyrimidylphosphoroth-ioicacidO,O’-diethyleste Ciazinon Oleodiazinon Dyzol Garden Tox {ha |
| PubChem Substance ID | 3017 |
| EC Number | 206-373-8 |
| Beilstein Registry Number | 273790 |
| MDL Number | MFCD00036204 |
| Chemical Name Translation | 二嗪农 |
| Merck Number | 13,3019 |
| Wiswesser Line Notation | T6N CNJ BY1&1 DOPS&O2&O2 F1 |
| LabNetwork Molecule ID | LN01269294 |
| InChI | InChI=1S/C12H21N2O3PS/c1-6-15-18(19,16-7-2)17-11-8-10(5)13-12(14-11)9(3)4/h8-9H,6-7H2,1-5H3 |
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现货库存
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分类
- {Chemicalbook} 农药: 杀虫（螨）剂: 有机磷杀虫剂
- {SNA} 2000/60/EC, Additional Standards, Analytical Standards, D, EPA, Endocrine Disruptors (Draft), European Community: ISO, DIN and DL 152, Insecticides, Method and Regulation Specific, Oeko-Tex Standard 100, Organophorous, Organophosphate, Pesticide Class, Pesticides, 农残和代谢标准品, 农残，疑似对蜜蜂有害, 分析/色谱, 按照字母排序
- 2000/60/EC, Acaricides, Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, D,
产品应用
- 非内吸性广谱杀虫剂、兼有一定的杀螨，杀线虫活性。广泛用于水稻、玉米、甘蔗、烟草、果树、蔬菜、牧草、花卉、森林和温室，用来防治多种刺激吸性和食叶性害虫。也用于土壤，防治地下害虫和线虫，还可用于防治家畜体外寄生虫和蝇类、蟑螂等家庭害虫。
- 校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。
相关文献及参考
- Short: IV/20A
- Merck: 14,2995
- Short: IV/20C
- Short: EINECS
- Short: IV/20B
- Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969);
安全信息
GHS Symbol
- H332 Harmful if inhaled 吸入有害
- H302 Harmful if swallowed 吞食有害
- H312 Harmful in contact with skin 皮肤接触有害
- H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
- H319 Causes serious eye irritation 严重刺激眼睛
- H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- P308+P313
- P301+P312+P330
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- R36 Irritating to eyes 刺激眼睛
- R11 Highly flammable 非常易燃
- R22 Harmful if swallowed 吞咽有害
- R50/53
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R51/53
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE
{TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976 Volume(issue)/page/year: -,-,1971/1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 76 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971 Volume(issue)/page/year:
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 3600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A131,1983
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 214 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness Skin and Appendages - sweating REFERENCE : CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 12,435,1978
TYPE OF TEST
TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 60 mg/L REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12,85,1988
TYPE OF TEST : DNA inhibition ROUTE OF EXPOSURE : Multiple routes TE
TYPE OF TEST : Mutation test systems - not otherwise specified ROUTE
TYPE OF TEST : Sister chromatid exchange ROUTE OF EXPOSURE : Multiple routes TEST SYSTEM : Fish - not otherwise specified DOSE/DURATION : 540 pmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 118,61,1983
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 100 mg/L/27H REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,277,1979
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 500 ug/L REFERENCE : BIHAA2 Bibliotheca Haematologica (Basel). (S. Karger AG, Postfach, CH-4009 Basel, Switzerland) No.1- 1955- Volume(issue)/page/year: 38(Pt 1),344,1971
TYPE OF TEST
TYPE OF TEST : DNA inhibition ROUTE OF EXPOSURE : Multiple routes TEST SYSTEM : Fish - not otherwise specified DOSE/DURATION : 640 ug/L REFERENCE : STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1972- Volume(issue)/page/year: 76,63,1988
{hazaTYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 150 mg/kg SEX/DURATION : female 11 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Nutritional and Gross Metabolic - weight loss or decreased weight gain Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 16,805,1968
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 26400 ug/kg SEX/DURATION : female 12-15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : JFMAAQ Journal of the Florida Medical Association. (Florida Medical Assoc., POB 2411, Jacksonville, FL 32203) V.1- 1914- Volume(issue)/page/year: 54,452,1967
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 63500 ug/kg SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE :
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - pig DOSE : 570 mg/kg SEX/DURATION : female 1-16 week(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproducti
其他信息
- 用途二:广谱性杀虫剂，具有触杀、胃毒、熏蒸和一定的内吸作用，也有较好的杀螨与杀卵作用。防治水稻螟虫、稻叶蝉，用50%乳油15～30g/100m 2 ，对水7.5kg喷雾，防效90%～100%。防治棉蚜、棉红蜂蛛、棉蓟马、棉叶蝉，用50%乳油7.5～12mL/100m 2 ，对水均匀喷雾，防效92%～97%。防治华北蝼蛄、华北大金龟子地下害虫，用50%乳油75mL，对水3.75kg，拌种45kg，推闷7h即可播种，或拌小麦种37kg，待种子把药液吸收，稍晾干后即可播种。防治菜青虫、菜蚜，用50%乳油6 ～7.5mL/100m 2 ,对水6 ～7.5kg均匀喷雾。防治葱潜叶蝇、豆类种蝇、稻瘿蚊，用50%乳油7.5～15mL/100m 2 ，对水7.5～15kg均匀喷雾。防治大黑蛴螬，用2%颗粒剂0.19kg/100m 2 穴施。注意勿与含铜杀菌剂和敌稗混合使用。
- 灭火剂:砂土、干粉、泡沫
- 方法二:将甲醇、氯化氢与异丁腈反应生成相应的亚氨酸酯盐酸盐；用氨处理，转化成相应的脒。然后，在碱性条件下，脒同乙酰乙酸乙酯缩合，得到嘧啶醇（4-羟基-2-异丙基-6-甲基嘧啶）。嘧啶醇在苯或甲苯中，在碳酸钠存在下加热回流，加入二乙基硫代磷酰氯、硝酸铜，缩合得到二嗪农。
- 急救治疗:[1]用阿托品1～5mg皮下或静脉注射(按中毒轻重而定) [2]用解磷定0.4－1.2g 静脉注射(按中毒轻重而定) [3]禁用吗啡、茶硷、吩噻嗪、利血平。 [4]误服立即引吐、洗胃、导泻(清醒时才能引吐)。
- 类别:农药
- 刺激数据:皮肤-兔子 500 毫克 中度;
- 用途三:非内吸性广谱杀虫剂，兼有一定的杀螨、杀线虫活性。广泛用于水稻、玉米、甘蔗、烟草、果树、蔬菜、牧草、花卉、森林和温室，用来防治多
- 职业标准:TWA 0.1 毫克/立方米; STEL 0.3 毫克/立方米
- 图谱信息:二嗪农(333-41-5)核磁图( 13 CNMR) 二嗪农(333-41-5)质谱(MS) 二嗪农(333-41-5)核磁图( 1 HNMR) 二嗪农(333-41-5)红外图谱(IR1)
- 储运特性:库房通风低温干燥; 与食品原料分开储运
- 上游原料:乙酰乙酸乙酯 --> 乙酰乙酸甲酯 --> 二乙基硫代磷酰氯 --> 喹硫磷 --> 异丁腈 --> 双二甲胺基乙基醚 --> 丁脒 --> 2-异丙基-6-甲基-4-吡啶醇 --> 环丙嘧啶醇 --> 6-甲基嘧啶
- 中毒症状:急性中毒多在12小时内发病，口服立即发病。轻度：头痛、头昏、恶心、呕吐、多汗、无力、胸闷、视力模糊、胃口不佳等，全血胆碱酯酶活力一般降 至正常值的70%以下。中度：除上述症状外还出现轻度呼吸困难、肌肉震颤 、瞳孔缩小、精神恍惚、行走不稳、大汗、流涎、腹疼、腹泻。重者还会出现昏迷、抽搐、呼吸困 难、口吐白沫、大小便失禁，惊厥，呼吸麻痹。
- 用途四:非内吸性广谱杀虫剂、兼有一定的杀螨，杀线虫活性。广泛用于水稻、玉米、甘蔗、烟草、果树、蔬菜、牧草、花卉、森林和温室，用来防治多种刺激吸性和食叶性害虫。也用于土壤，防治地下害虫和线虫，还可用于防治家畜体外寄生虫和蝇类、蟑螂等家庭害虫。校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。
- Sigma Aldrich:333-41-5(sigmaaldrich)
- 方法一:O，O-二乙基硫代磷酰氯的制备 详见喹硫磷的合成。 2-异丙基-4-甲基-6-羟基嘧啶的制备 由异丁腈与甲醇和盐酸反应，制得亚胺醚盐酸盐，再与氨作用制得异丁脒。异丁脒与乙酰乙酸乙酯在氢氧化钠存在下环化制得2-异丙基-4-甲基-6-羟基嘧啶。 二嗪磷的合成 将8g 2-异丙基-4-甲基-6-羟基嘧啶、0.63g SMB、2.82g氢氧化钠、50mL丁酮混合后，在室温下搅拌0.5h，缓慢升温至55℃，至物料澄清后加入9.5g O，O-二乙基硫代磷酰氯，并升温至70℃，搅拌0.5h，再回流1h，搅冷，加入50mL水，使析出固体溶解，用20%NaOH调节pH值至11，搅拌、分层。水层用丁酮萃取，溶剂合并，减压脱溶，残留物经碱洗、酸洗、再碱洗后，水洗至中性，减压加热脱水，得14g棕色透明液体，折射率1.4942。
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