Hydrazinecarboxamide 氨基甲酰肼

CAS 57-56-7 MFCD00042824

化学结构图

57-56-7
SMILES: NNC(N)=O

化学属性

Mol. FormulaCH5N3O
Mol. Weight75.07
Appearance 白色片状结晶。熔点96℃。易溶于水，不溶于乙醇和乙醚。易潮解。
Melting Point96 °C
Boiling Point133.71 °C at 760 mmHg

别名和识别编码

Chemical NameHydrazinecarboxamide
Synonym Hydrazinecarboxamide {LY} Hydrazinecarboxamide {} {LY} Hydrazinecarboxamide {} {} {LY} Hydrazinecarboxamide {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrazin
MDL NumberMFCD00042824
CAS Number57-56-7
PubChem Substance ID5196
EC Number200-339-6
Chemical Name Translation氨基甲酰肼
Wiswesser Line NotationZVMZ
Beilstein Registry Number0506319
LabNetwork Molecule IDLN01075682
InChIInChI=1S/CH5N3O/c2-1(5)4-3/h3H2,(H3,2,4,5)
Canonical SMILESNNC(N)=O
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分类

  • {uni_hamburg} no charge; urea; 1fragment
  • {SNA} Chemical Synthesis, Derivatization Reagents, Derivatization Reagents HPLC, Fluorescence, Hydrazides, Scavengers, Silica Gel, Solid Supported Synthesis, Specialty Synthesis, 分析/色谱, 分析试剂
  • {SNA} Analytical Reagents, Analytical/Chromatography, Chemical Synthesis, Derivatization Reagents, Derivatization Reagents HPLC, Fluorescence, Hydrazides, Scavengers, Silica Gel, Solid Supported Synthesis, Specialty Synthesis

相关文献及参考

  • Structure Index 1 , 147:C:1
  • Short: IV/20B Title: Vapor Pressure and Antoine Coefficients for Oxygen Containing Organic Compounds Author: Dykyj, J.; Svoboda, J.; Wilhoit, R.C.; Frenkel, M.; Hall, K.R. Editor: Hall, K.R. Source: Landolt-Börnstein, New Series Volume: IV/20B Year: 2000 Keyword: organic compounds; vapor pressure ISBN: 3-540-64968-9 ISBN: 978-3-540-64968-7 Internet Resource: DOI:10.1007/b71424 RefComment: VII, 320 pages.
  • Short: IV/20C Title: Vapor Pressure and Antoine Coefficients for Nitrogen Containing Organic Compounds Author: Dykyj, J.; Svoboda, J.; Wilhoit, R.C.; Frenkel, M.; Hall, K.R. Editor: Hall, K.R. Source: Landolt-Börnstein, New Series Volume: IV/20C Year: 2001 Keyword: organic compounds; vapor pressure ISBN: 3-540-41060-0 ISBN: 978-3-540-41060-7 Internet Resource: DOI:10.1007/b88812 RefComment: VII, 197 pages
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

WGK Germany3
Hazard Codes Xn
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 gm/kg/30W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   51,83,1960

RTECSVT2975000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle
   Pathologie.  (Berlin, Ger.) V.254-263, 1966-69.  For publisher information,
   see NSAPCC.  Volume(issue)/page/year: 257,296,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 176 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 122,110,1958

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 122,110,1958

TYPE OF TEST            : LD50 - Le

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 126 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 122,110,1958

{hazard_co

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 125 ug/well
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 133,161,1984

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 67 umol/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   41,1469,1981

Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P316
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Storage condition

其他信息

  • Sigma Aldrich:57-56-7(sigmaaldrich)
  • MOL 文件:57-56-7.mol
  • 方法一:1.尿素-水合肼合成法由尿素与水合肼缩合而得。将40%的水合肼和尿素按摩尔比1.515：1投入反应锅中混合，搅拌加热，于95-103℃回流8h。降温过滤，得氨基脲水溶液，可直接用于有机合成。有时候也将氨基脲水溶液加盐酸，放置后过滤，得到盐酸氨基脲[CAS：563-41-7]。盐酸氨基脲的熔点为175℃。2.硫酸肼-氰酸钠法硫酸肼与氰酸钠反应制得。
  • 下游产品:氢化可的松 --> 对甲基苯乙酮 --> 盐酸氨基脲 --> (Z)-9-环十七烯-1-酮 --> 2,6-二羟基嘌呤 --> 呋喃妥因 --> 薄荷酮 --> 酮麝香 --> 4-苯基脲唑 --> 丙酮缩氨脲
  • 用途一:有机合成原料，也是医药、农药的中间体和测定醛、酮的试剂。用于生产呋喃西啉、硝基呋喃妥因等药物。
  • 上游原料:尿素 --> 硫酸肼 --> 氰酸钠 --> 盐酸氨基脲

系列性分类

  1. Chemical Synthesis 化学合成
  2. Specialty Synthesis 特殊合成技术
  3. Solid Supported Synthesis - Specialty Synthesis
  4. Silica Gel - Solid Supported Synthesis
  5. Scavengers - Silica Gel
  1. Chemical Synthesis 化学合成
  2. Specialty Synthesis 特殊合成技术
  3. Solid Supported Synthesis - Specialty Synthesis
  4. Silica Gel - Solid Supported Synthesis
  5. Scavengers - Silica Gel
  1. Functional Group 官能团索引
  2. semicarbazide

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