3,3'-Dichlorobenzidine 3,3-二氯联苯胺

CAS 91-94-1 MFCD00043917

化学结构图

91-94-1
SMILES: Nc1ccc(-c2ccc(N)c(Cl)c2)cc1Cl

化学属性

Mol. FormulaC12H10Cl2N2
Mol. Weight253.14
Flash Point10 °C
Solubility微溶于水,溶于醇、醚、稀酸。

别名和识别编码

Chemical Name3,3'-Dichlorobiphenyl-4,4'-diamine
CAS Number91-94-1
Alfabeta NameDICHLOROBIPHENYLDIAMINE 3344---,,''
MDL NumberMFCD00043917
EC Number202-109-0
Synonym (1,1'-Biphenyl)-4,4'-diamine, 3,3'-dichloro- 1’-Biphenyl]-4,4’-diamine,3,3’-dichloro-[1 1’-biphenyl)-4,4’-diamine,3,3’-dichloro-( 1’-biphenyl]-4,4’-diamine,3,3’-dichloro-[ 3,3 Dichlorobenzidine 3,3' Dichlorobenzidine 3,3'-DICHLOROBENZIDINE 3,3'-Dichlorbenzidin 3,3'-Dichloro-4,4'-biphenyldiamine 3,3'-Dichloro-4,4'-diamino(1,1-biphenyl) 3,3'-Dichloro-4,4'-diaminobiphenyl 3,3'-Dichlorobenzidina 3,3'-Dichlorobenzidine 3,3'-Dichlorobiphenyl-4,4'-diamine 3,3'-二氯-4,4'-二胺聯苯 3,3'-二氯联苯-4,4'-二胺 3,3'-双氯苯甲酸酯 3,3-Dichloro-[1,1]-biphenyl-4,4-diamine 3,3-Dichlorobenzidine 3,3-二氯联苯胺 3,3’-dichlorbenzidin 3,3’-dichloro(1,1’-biphenyl)-4,4’-diamine 3,3’-dichloro-4,4’-biphenyldiamine
Chemical Name Translation3,3-二氯联苯胺
Wiswesser Line NotationZR BG DR DZ CG
Beilstein Registry Number2108022
LabNetwork Molecule IDLN00166125
PubChem Substance ID7070
InChIInChI=1S/C12H10Cl2N2/c13-9-5-7(1-3-11(9)15)8-2-4-12(16)10(14)6-8/h1-6H,15-16H2
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相关文献及参考

  • Merck: 14,3059

安全信息

Warnings 危化品目录(2015) IRRITANT
Hazard Codes T,N,F
Storage condition 2-8°C
UN Number UN 3077 9/PG 3
Safety Statements
  • S7 Keep container tightly closed 保存在严格密闭容器中;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
WGK Germany3
RTECSDD0525000
Risk Statements
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性:吸入,皮肤接触和吞食都会产生十分严重的不可逆危险
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R11 Highly flammable 非常易燃
  • R45 May cause cancer 可能致癌
  • R21 Harmful in contact with skin 与皮肤接触有害
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R52/53
  • R50/53
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 320 mg/kg
                          female 15-21 day(s) after conception
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Reproductive - Tumorigenic effects - transplacental tumorigenesis
   Lungs, Thorax, or Respiration - tumors
REFE

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7 gm/kg/43W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   VOONAW Voprosy Onkologii.  Problems of Oncology.  For English translation,
   see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-10,
   1928-37; V.1-    1955-  Volume(issue)/page/year: 5(5),524,1959

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3600 mg/kg/61W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - breast
REFERENCE :
   VOONAW Voprosy Onkologii.  Problems of Oncology.  For English translation,
   see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-10,
   1928-37; V.1-    1955-  Volume(issue)/page/year: 21(6),110,1975

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 17 gm/kg/7Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   DUPON* E.I. Dupont de Nemours and Company, Technical Sheet.  (1007 Market
   St.,

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 ug/plate
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   4,21,1977

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 100 nmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Kidney
DOSE/DURATION           : 80 ug/L
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   37,873,1978

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 25500 nmol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   38,369,1982

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 nmol/plate
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 2,225,1987

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 2,267,1987

TYPE OF TEST            : Body fluid assay
TES

Hazard statements
  • H312 Harmful in contact with skin 皮肤接触有害
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H350 May cause cancer 可能致癌
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P203
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P302+P352
  • P304+P340
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P317
  • P318
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P333+P313
  • P333+P317
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Restrict 危险品

其他信息

  • 灭火剂:干粉, 砂土, 泡沫, 二氧化碳
  • 毒性分级:中毒
  • Sigma Aldrich:91-94-1(sigmaaldrich)
  • 可燃性危险特性:可燃; 受热放出有毒氯化氢, 氮氧化物气体
  • 储运特性:库房通风低温干燥; 与氧化剂, 食品分开储运
  • 用途一:用作染料、颜料中间体
  • MOL 文件:91-94-1.mol
  • 急性毒性:口服-大鼠 LD50: 3820 毫克/公斤口服-小鼠 LD50: 2464 毫克/公斤
  • 外观性质:棕褐色针状结晶,易氧化。
  • MSDS 信息:3,3'-二氯联苯胺(91-94-1).msds
  • 下游产品:2,2'-(3,3'-二氯-1,1'-联苯-4,4'-双偶氮)双(N-苯基-3-氧代-丁酰胺) --> 4,4'-[[3,3'-二氯(1,1'-联苯)-4,4'-二基]二(偶氮)]二[2,4-二氢-5-甲基-2-苯基-3H-吡唑-3-酮]
  • 类别:有毒物品

系列性分类


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