Antazoline 安他唑啉

CAS 91-75-8 MFCD00047013

化学结构图

91-75-8
SMILES: c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1

化学属性

Mol. FormulaC17H19N3
Mol. Weight265.39
Appearance 晶体。熔点120-122℃。其盐酸盐[2508-72-7]为白色结晶性粉末，熔点237-241℃。溶于乙醇，略溶于水，不溶于氯仿、乙醚、苯。

别名和识别编码

Chemical NameAntazoline
MDL NumberMFCD00047013
Chemical Name Translation安他唑啉
Synonym 4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine n-benzyl-n-(4,5-dihydro-1h-imidazol-2-ylmethyl)aniline BENZYL-(4,5-DIHYDRO-1H-IMIDAZOL-2-YLMETHYL)-PHENYL-AMINE 0.5 H2SO4 Azalone 2-(N-Benzylanilinomethyl)-2-imidazoline Antistine N-苄基-N-(4,5-二氢-1H-咪唑-2-基甲基)苯胺 2-(N-PHENYL-N-BENZYL-AMINOMETHYL)-IMIDAZOLINE 0.5 H2SO4 albalon-a 2-(N-Phenyl-N-benzylaminomethyl)imidazoline 2-Phenyl-benzyl-amino-methylimidazolin 2-Imidazoline, 2-[(N-benzylanilino)methyl]- ANTAZOLINE 0.5 H2SO4 Ben-A-hist Antihistal 5512-M Phenazoline 盐酸安太林 Antazolin 1H-Imidazole-2-methanamine, 4,5-dihydro-N-phenyl-N-(phenylmethyl)- 安他心 Antazoline ANTAZOLINE 2-[(N-Benzylanilino)methyl]-2-imidazol 安他唑啉 Analergine Imidamine Antastan Allergan A 2-[(N-Benzylanilino)methyl]-2-imidazoline Antistin Histostab Antasten
CAS Number91-75-8
EC Number202-094-0
Wiswesser Line NotationT5M CN BUTJ B1N1R&R
Beilstein Registry Number0233924
LabNetwork Molecule IDLN01343793
PubChem Substance ID2200
InChIInChI=1S/C17H19N3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,19)
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安全信息

RTECSNJ2000000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 61 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 188,189,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 398 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 7,237,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 17,214,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 237,171,1959

其他信息

  • MOL 文件:91-75-8.mol
  • 用途一:抗心律失常药，亦可用作抗组织胺药物。
  • MSDS 信息:Albalon-A(91-75-8).msds

系列性分类

  1. Functional Group 官能团索引
  2. carboxylic acid amidine

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