Mecillinam

CAS 32887-01-7 MFCD32887017

化学结构图

32887-01-7
SMILES: CC1(C)S[C@@H]2[C@H](/N=C/N3CCCCCC3)C(=O)N2[C@H]1C(O)=O

化学属性

Mol. Weight325.47
Mol. FormulaC15H23N3O3S

别名和识别编码

CAS Number32887-01-7
Chemical NameMecillinam
Synonym Mecillinam Penicillin HX (2S,5R,6R)-6-[[(Hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Ro 10-9070 Amdinocillin Mecilinamo FL 1060 Hexacillin FL-1060, Ro-9070, Mecillinam, 6-[[(Hexahydro-1H-azepin-1-yl)methylene] 6-((Hexahydro-1H-azepin-1-yl)methyleneamino)penicillanic acid Selexidin
Wiswesser Line NotationT45 ANV ESTJ F1 F1 GVQ CNU1- AT7NTJ
Chemical Name Translation
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds

产品应用

  • Active antibacterial against gram-negative bacteria.

相关文献及参考

  • Cagnacci, S., et al.: J. Clin. Microbiol., 46, 2605 (2008),
  • Obach, R., et al.: Drug Metab. Disposition, 36, 1385 (2008),
  • Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008),

安全信息

RTECSXI0185000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya.  (Izdatel'stvo
   Zinantne, Riga, USSR) No.1-    1970-  Volume(issue)/page/year: 9,91,1980

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TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1500 mg/kg
TOXIC EFFECTS :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >20 gm/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya.  (Izdatel'stvo
   Zinantne, Riga, USSR) No.1-    1970-  Volume(issue)/page/year: 9,91,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   16,191,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3500 mg/kg
TOXIC EFFECTS :
   Blood - other changes
REFERENCE :
   EKFMA7 Eksperimental'naya i Klinicheskaya Farmako

系列性分类

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