1-Chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol 1-(3-氯-2-羟基丙基)-2-甲基-5-硝基咪唑

CAS 16773-42-5 MFCD00057960

化学结构图

16773-42-5
SMILES: CC1=NC=C(N1CC(O)CCl)[N+]([O-])=O

化学属性

Mol. FormulaC7H10ClN3O3
Mol. Weight220
Melting Point90.0 to 94.0 deg-C
TSCANo

别名和识别编码

Chemical Name1-Chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
CAS Number16773-42-5
Alfabeta NameCHLOROMETHYLNITROIMIDAZOLYLPROPANOL H1325112()------------
MDL NumberMFCD00057960
Synonym Ro 7-0207 1-(3-Chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole 1H-Imidazole-1-ethanol, alpha-(chloromethyl)-2-methyl-5-nitro- alpha-(Chlormethyl)-2-methyl-5-nitro-imidazol-1-aethanol alpha-(Chloromethyl)-2-methyl-5-nitro-1H-imidazole-1-ethanol Tiberal 奥硝唑 1(3-chloro-2-hydroxypropyl)-2-methyl-5-nitro imidazole; alpha-(chloromethyl)-2-methyl-5-nitro-1H-Imidazole-1-ethanol Ornidazole ?-(Chloromethyl)-2-methyl-5-nitro-
PubChem Substance ID253659868
EC Number240-826-0
Merck Number6872
Chemical Name Translation1-(3-氯-2-羟基丙基)-2-甲基-5-硝基咪唑
Wiswesser Line NotationT5N CNJ A1YQ1G B1 ENW
Beilstein Registry Number0614299
Reaxys-RN614299
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分类

  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine ChemicalsHeterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds, O

产品应用

  • Anti-infective.

相关文献及参考

  • Grunberg, E, et al.: Proc. Soc. Exp. Biol. Med., 133, 490 (1970),
  • Hoffer, M., et al.: J. Med. Chem., 17, 1019 (1974),
  • Schwartz, D.E., et al.: Chemotherapy, 22, 19 (1976),

安全信息

Warnings IRRITANT
GHS Symbol
Signal word Warning
Hazard statements
  • H302 Harmful if swallowed 吞食有害
WGK Germany3
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
RTECSNI5460000
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1780 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 28,612,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 375 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 28,612,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1120 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 28,612,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 28,612,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Klebsiella pneumoniae
DOSE/DURATION           : 50 umol/L/20H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 66,207,1979

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 200 nmol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 58,1,1978

TYPE OF TEST            : Host-mediated assay
TEST SYSTEM             : Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 86,243,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 35 gm/kg
SEX/DURATION            : male 61 day(s) pre-mating
                          female 14 day(s) pre-mating  - 13 day(s) after
                          conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   92,480,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 11200 mg/kg
SEX/DURATION            : male 4 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 25600 mg/kg
SEX/DURATION            : male 64 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   92,480,1988

Precautionary statements
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

系列性分类


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