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分类

• {SNA} A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Antiviral, Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Chemical Structure Class, Endoplasmic Reticulum Stress, Enzymes, Inhibitors, and Substrates, Epipolythiodioxopiperazines, G, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, Inhibitors, Inhibits an Enzyme, Interferes with DNA Synthesis, Mechanism of Action, Mold,
• {SNA} A - K,
• {SNA} All alphabeticall

产品应用

• A toxic epipolythiodioxopiperazine metabolite that induces apoptosis and inhibits NF-κB

相关文献及参考

• Short: III/5a Title: Structure Data of Organic Crystals: C ... C 13 Author: Schudt, E.; Weitz, G. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/5a Year: 1971 ISBN: 3-540-05177-5 ISBN: 978-3-540-05177-0 Internet Resource: DOI:10.1007/b19970 RefComment: XXI, 736 pages, and VII, 890 pages. Hardcover Abstract: Volume III/5 offers a compitation as complete as possible of the space groups and lattice con-stants of all crystals which have been studied by means of X-rays, neutron and electron diffraction.

安全信息

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CMTRAG Chemotherapia.  (Basel, Switzerland)  V.1-12, 1960-67.  For publisher
   information, see CHTHBK.  Volume(issue)/page/year: 10,12,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 32 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CMTRAG Chemotherapia.  (Basel, Switzerland)  V.1-12, 1960-67.  For publisher
   information, see CHTHBK.  Volume(issue)/page/year: 10,12,1965

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
   JACSAT Journal of the American Chemical Society.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1879-  Volume(issue)/page/year: 65,2005,1943

TYPE OF TEST            : LD50 - Lethal dose, 50 per

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VHTODE Veterinary and Human Toxicology.  (American College of Veterinary and
   Comparative Toxicology, Publication Office, Comparative Toxicology,
   Manhattan, KS 66506)  V.19-    1977-  Volume(issue)/page/year:
   32(Suppl),63,1990

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 250 mg/L
REFERENCE :
   MYCPAH Mycopathologia.  (Kluwer Academic Pub. Group, Distribution Centre,
   POB 322, 3300 AH Dordrecht, Netherlands)  V.1-    1938-
   Volume(issue)/page/year: 87,43,1984

其他信息

• Gliotoxin, a toxic epipolythiodioxopiperazine metabolite, has been shown to be an immunosuppressive mycotoxin. This agent displays a capacity to induce macrophagocytic, thymocytic, splenocytic, and mesenteric lymph node cell apoptosis and inhibit transcription factor NF-κB activation. Mechanistic studies suggest that this inhibition is done via a suppression of proteasome-mediated degradation of IκB-α. Additional research reports that Gliotoxin is capable of down-regulating inflammation and suppressing TNFα IL-1α and mRNA expression. Gliotoxin is an inhibitor of Farnesyl Transferase and GGTase. Gliotoxin is an inhibitor of 20S Proteasome. Gliotoxin exhibits inhibitory activities against histone H3K9 methyltransferase, a key enzyme in the regulation of transcriptional activity by writing epigenetic marks.