2H-1,4-Benzodiazepin-2-one,1,3-dihydro-7-nitro-5-phenyl- 硝西泮溶液，100ppm
CAS 146-22-5 MFCD00058577
化学结构图
SMILES: [O-][N+](=O)C1C=C2C(=NCC(=O)NC2=CC=1)C1C=CC=CC=1
化学属性
| Mol. Formula | C15H11N3O3 |
|---|---|
| Mol. Weight | 281.29 |
| Appearance | 淡黄色片状结晶。熔点226-229℃（分解）。溶于乙醇、丙酮、氯仿、乙酸乙酯、二氯甲烷，不溶于水、乙醚、苯和已烷。无臭，无味。 |
别名和识别编码
| Chemical Name | Nitrazepam |
|---|---|
| CAS Number | 146-22-5 |
| Synonym | 1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one Sonnolin Mogadan 1,3-dihydro-7-nitro-5-phenyl-2h-4-benzodiazepin-2-one 5-苯基-7-硝基-1,3-二氢-2H-1,4-苯并二氮卓-2-酮 Eunoktin Hipsal Dormin-5 Neozepam 7-Nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one 7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one 7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one NITRAZEPAM Hipnax Nitrados Ro 5-3059 Epinelbon Ro 4-5360 Mogadon Dumolid Apodorm 1,3-二氢-7-硝基-5-苯基-2H-1,4-苯并二氮杂酮-2 Paxisyn 5-苯基-7-硝基-1,3-二氢-2H-1,4-苯并二氮杂卓-2-酮 Benzalin Nitrenpax 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-nitro-5-phenyl- 硝基安定 Relact 消酮 NSC-58775 Mogadone 1H-1,4-Benzodiazepin-2(3H)-one, 7-chloro-3-isopropyl-5-phenyl- Eunoctin Radedorm 1,3-dihydro-7-nitro-5-phenyl-2h-1,4-benzodiazepin-2-one LA 1 Cerson Eatan Nitrazepam Pelson 硝西泮 Calsmin Epibenzalin |
| MDL Number | MFCD00058577 |
| PubChem Substance ID | 24897666 |
| EC Number | 205-665-2 |
| Chemical Name Translation | 硝西泮溶液，100ppm |
| Wiswesser Line Notation | T67 GMV JN IHJ CNW KR |
| Beilstein Registry Number | 0757185 |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- Amines
- Aromatics
- Heterocycles
- Neurochemicals
- Pharmaceuticals
- Intermediates & Fine Chemicals
- {SNA} Benzodiazepines and Anxiolytics, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, N, Neurobiology, Neuroscience, Pharmacologicals
产品应用
- Anticonvulsant; hypnotic.
相关文献及参考
- Rieder, et al.: Arzneim.-Forsch., 23, 212 (1973),
- Kangas, L., Acta Pharmacol. Toxicol., 45, 16 (1979),
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 825 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 520 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,165,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >400 mg/kg TOXIC EFFECTS : Behavioral - excitement REFERENCE : SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 95,334,1965
TYPE OF TEST
TYPE OF TEST : LD50 - Lethal dose, 50 per
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 733 mg/kg TOXIC EFFECTS : Behavioral - anticonvulsant REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 20,952,1977
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 1667 ug/plate REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,12,1987
TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 2 mg/9D REFERENCE : SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 11,718,1975
TYPE OF TEST : Specific locus test ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 5000 PPM REFERENCE : CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O., Bangalore 560 080, India) V.1- 1932- Volume(issue)/page/year: 57,682,1988
TYPE OF TEST : Sperm Morphology ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 300 mg/kg/15D (Continuous) REFERENCE : CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 36,45,1983
TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 300 mg/kg/15D (Intermittent) REFERENCE : INDRBA Indian Drugs. (Indian Drugs Manufacturers' Assoc., 102B, Poonam Chambers, Dr. A. B. Rd., Worli, Bombay 400 018, India) V.1- 1963- Volume(issue)/page/year: 22,410,1985
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 100 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 46,437,1984
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 200 mg/kg SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 69,59,1990
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 300 mg/kg SEX/DURATION : female 12 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 69,59,1990
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE
其他信息
- 图谱信息:硝西泮(146-22-5)核磁图( 13 CNMR) 硝西泮(146-22-5)质谱(MS) 硝西泮(146-22-5)红外图谱(IR2) 硝西泮(146-22-5)红外图谱(IR1) 硝西泮(146-22-5)核磁图( 1 HNMR)
- 上游原料:乌洛托品 --> 苯甲酰氯 --> 氯乙酰氯 --> 4-氯苯胺 --> 氯乙酰胺 --> 2-氨基-5-硝基二苯甲酮
- 方法一:2-氨基-5-硝基二苯酮（见02420）溶于干燥的苯，搅拌下滴加氯乙酰氯，升温回流4h，生成2-氯乙酰胺基-5-硝基二苯酮。将基与六次甲基四胺和乙醇加热回流20h，然后蒸馏回收乙醇，过滤得到粗品，再经脱以重结晶，得硝西泮成品。
- MOL 文件:146-22-5.mol
- Sigma Aldrich:146-22-5(sigmaaldrich)
- 用途一:该品为苯二氮类药，具有催眠、松驰肌肉、抗惊厥和抗焦虑作用。服药15-30min入睡，持续6-8h，接近自然睡眠。
京ICP备2020036287号