Puromycin aminonucleoside 3'-氨基-3'-脱氧-N,N-二甲基腺苷

CAS 58-60-6 MFCD00063462

化学结构图

58-60-6
SMILES: CN(C)c1ncnc2c1ncn2C1OC(CO)C(N)C1O

化学属性

Mol. FormulaC12H18N6O3
Mol. Weight294
Density1.7
SolubilitySoluble in water (10 mg/ml)

别名和识别编码

Chemical NamePuromycin aminonucleoside
MDL NumberMFCD00063462
CAS Number58-60-6
Synonym 3′-Amino-3′-deoxy-N6,N6-dimethyladenosine 氨基核苷嘌呤霉素 3'-Amino-3'-deoxy-N6,N6-dimethyladenosine Stylomycin aminonucleoside Aminonucleoside 博罗霉素氨基核苷 Puromycin aminonucleoside Aminonucleoside puromycin SAN
PubChem Substance ID6020
Beilstein Registry Number93902
EC Number200-388-3
Chemical Name Translation3'-氨基-3'-脱氧-N,N-二甲基腺苷
InChIKeyRYSMHWILUNYBFW-GRIPGOBMSA-N
Wiswesser Line NotationT56 BN DN FN HNJ IN1&1 D- BT5OTJ CQ DZ E1Q
LabNetwork Molecule IDLN01327490
InChIInChI=1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7-,9-,12-/m1/s1
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分类

  • {SNA} Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Biochemicals and Reagents, Genetic Marker Selection, Interferes with Protein Synthesis, L - Z, Mechanism of Action, Spectrum of Activity
  • {SNA} Antibacterial, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Genetic Marker Selection, Interferes with Protein Synthesis, L - Z, Mechanism of Action, Spectrum of Activity, 抗生素, 生化试剂
  • {SNA} Antibacterial,

产品应用

  • The aminonucleoside portion of the antibiotic puromycin.

相关文献及参考

  • [2]. Wada T, et al. Prevents podocyte apoptosis induced by puromycin aminonucleoside: role of p53 and Bcl-2-related family proteins. J Am Soc Nephrol. 2005 Sep;16(9):2615-25.
  • [3]. Gong W, et al. Estrogen-related receptor-α mediates puromycin aminonucleoside-induced mesangial cell apoptosis and inflammatory injury. Am J Physiol Renal Physiol. 2019 May 1;316(5):F906-F913.
  • [4]. Xia L, et al. Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleosidenephrotoxicity. Am J Physiol Renal Physiol. 2009 Jun;296(6):F1307-13.
  • [5]. Kawakami H, et al. Dynamics of absolute amount of nephrin in a single podocyte in puromycin aminonucleoside nephrosis rats calculated by quantitative glomerular proteomics approach with selected reaction monitoring mode. Nephrol Dial Transplant. 2012 Apr;
  • [6]. Nosaka K, et al. An adenosine deaminase inhibitor prevents puromycin aminonucleoside nephrotoxicity. Free Radic Biol M

安全信息

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
GHS Symbol
WGK Germany3
Hazard statements
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
Signal word Warning
Hazard Codes Xn
Risk Statements
  • R48/22
Storage condition 储存温度2-8°C
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
RTECSAU7337000 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Lung
DOSE/DURATION           : 6 mg/L
REFERENCE :
   JCLLAX Journal of Cellular Physiology.  (Alan R. Liss, Inc., 41 E. 11th St.,
   New York, NY 10003) V.67-    1966-  Volume(issue)/page/year: 81,71,1973

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 83 mg/kg
REFERENCE :
   JCLBA3 Journal of Cell Biology.  (Rockefeller Univ. Press, 1230 York Ave.,
   New York, NY 10003) V.12-    1962-  Volume(issue)/page/year: 30,13,1966

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lung
DOSE/DURATION           : 6 mg/L
REFERENCE :
   JCLLAX Journal of Cellular Physiology.  (Alan R. Liss, Inc., 41 E. 11th St.,
   New York, NY 10003) V.67-    1966-  Volume(issue)/page/year: 81,71,1973

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Lung
DOSE/DURATION           : 100 mg/L
REFERENCE :
   JCLLAX Journal of Cellular Physiology.  (Alan R. Liss, Inc., 41 E. 11th St.,
   New York, NY 10003) V.67-    1966-  Volume(issue)/page/year: 81,71,1973

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 83 mg/kg
REFERENCE :
   JCLBA3 Journal of Cell Biology.  (Rockefeller Univ. Press, 1230 York Ave.,
   New York, NY 10003) V.12-    1962-  Volume(issue)/page/year: 30,13,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 105 ug/kg
SEX/DURATION            : female 5-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 195,1209,1962

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 45 mg/kg
SEX/DURATION            : female 8-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   NPRNAY Nephron.  (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003)
   V.1-    1964-  Volume(issue)/page/year: 3,344,1966

其他信息

  • Puromycin Aminonucleoside (3'-Amino-3'-deoxy-N6,N6-dimethyladenosine) is the aminonucleoside portion of the antibiotic puromycin. It is a puromycin analog which does not inhibit protein synthesis or induce apoptosis. Used in the study of focal and segmental glomerulosclerosis and in the induction of nephrosis in rats. The excretion of sodium and NOx metabolites in rats with puromycin aminonucleoside-induced nephrotic syndrome has been studied. Used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics N-S - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics N-S - Antibiotics A to Z
  1. Medical Research Areas
  2. L01-Proteases (36) ||[cs]: . Proteases
  3. DPP-4 / Dipeptidyl Peptidase  (二肽基肽酶)
  1. Medical Research Areas
  2. Metabolism
  3. Aminopeptidase  (氨肽酶)

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