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分类

• {SNA} anionic
• {SNA} Anionic Detergents, Antigen-Vaccine Preparation, Bile Salts, Bile acids and Derivatives, Cell Culture, Cell Lysis Reagents, Core Biore
• {SNA} Anionic Detergents, Antigen-Vaccine Preparation, Bile Salts, Bile acids and Derivatives, Biochemicals and Reagents, Cell Culture, Core Bioreagents, Detergents, Detergents N to Z, Detergents by Applications, Diagnostic Applications, Drug Delivery-Liposomes, Electrophoresis Chromatography, Lipids, Membrane Protein Solubilization, Molecular Biology, Research Essentials, Sterol Lipids

产品应用

• An ionic detergent for the solubilization of membrane-bound proteins.

相关文献及参考

• [2]. Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in micedependent on c-Myc expression. Cancer Med. 2017 Apr;6(4):788-797.
• Hayashi, I. and Majima M Br. J. Pharmacol. 126 , 197, (1999) 摘要
• Iwata, Y., et al., Characterization of a calcium-dependent protein kinase of tobacco leaves that is associated with the plasma membrane and is inducible by sucrose. Plant Cell Physiol. 39 , 1176-1183, (1998) 摘要
• Janssen, M.J., et al., Stability of solubilized benzodiazepine receptors. Prep Biochem Biotechnol. 27 , 209-217, (1997) 摘要
• Ochsenkuhn, T., et al. Cancer 85 , 1664, (1999) 摘要
• Storrie, B. and Madden, E.A., Isolation of subcellular organelles. Meth. Enzymol. 182 , 203-225, (1990) 摘要
• [1]. So
• [1]. Somm E, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017 Apr 20;2(8). pii: 91809.

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 20,323,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 123 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 3,45,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2430 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 3,45,1969

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Blood - other changes
REFERENCE :
   ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin.  (Berlin, Fed.
   Rep. Ger.)  V.1-139, 1913-65.  For publisher informa

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 960 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 93,101,1982

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 pph/3H
REFERENCE :
   CSHSAZ Cold Spring Harbor Symposia on Quantitative Biology.  (Cold Spring
   Harbor Laboratory, POB 100, Cold Spring Harbor, NY 11724)  V.1-    1933-
   Volume(issue)/page/year: 12,256,1947

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 100 mg/L
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 28,504,1982

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 25 mg/L
REFERENCE :
   NUCADQ Nutrition and Cancer.  (Franklin Institute Press, POB 2266,
   Phildelphia, PA 19103) V.1-    1978-  Volume(issue)/page/year: 16,227,1991

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Rectal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 10 umol/kg
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   75,29,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1400 mg/kg
SEX/DURATION            : male 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 3,45,1969

其他信息

• MOL 文件:302-95-4.mol
• 脱氧胆酸钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 69022780 脱氧胆酸钠;去氧胆酸钠 10g 62元 2011/04/16 C0316 脱氧胆酸钠 Sodium Deoxycholate 25G 540元 2011/04/16 D1820 脱氧胆酸钠[用于电泳] Sodium Deoxycholate [for Electrophoresis] 25G 1010元
• Acros Organics:脱氧胆酸钠 Deoxycholic acid, sodium salt, extra pure, 99%(302-95-4)
• 类似胆汁气味。有强烈苦味。易吸湿。易溶于水，微溶于无水醇，不溶于醚。水中溶解度:330 g/L (15°C)
• 用途一:阴离子去垢剂，用于抽提膜受体和其它的膜蛋白，也用于核分离。也用于配制细菌培养基，代替脑磷脂作胆固醇絮状试验。
• MSDS 信息:Sodium deoxycholate(302-95-4).msds
• 图谱信息:脱氧胆酸钠(302-95-4)核磁图( 13 CNMR) 脱氧胆酸钠(302-95-4)红外图谱(IR2) 脱氧胆酸钠(302-95-4)红外图谱(IR1)
• 比旋光度:44 ° (c=2, H2O)
• F:3-10
• TCI Shanghai:脱氧胆酸钠[用于电泳] Sodium Deoxycholate [for Electrophoresis],>;98.0%(T)(302-95-4)
• 外观性质:白色结晶性粉末。类似胆汁气味。有强烈苦味。易吸湿。易溶于水，微溶于无水醇，不溶于醚。水中溶解度:330 g/L (15°C)比旋光度[α]20D 42 ° (C=2, H2O) 熔点：360 °C
• Sodium deoxycholate is an ionic detergent for the solubilization of membrane-bound proteins. Deoxycholic Acid, Sodium Salt is reported to induce tyrosine phosphorylation of b-catenin and its subsequent translocation to the nucleus, promoting activation of β-catenin signaling (effective concentration 5-50 μM).
• 海关编码:29181930
• Sigma Aldrich:302-95-4(sigmaaldrich)