L-Arginine monohydrochloride L-精氨酸单盐酸盐

CAS 1119-34-2 MFCD00064550

化学结构图

1119-34-2
SMILES: Cl.N=C(N)NCCC[C@H](N)C(=O)O

化学属性

Mol. FormulaC6H15ClN4O2
Mol. Weight210.66
Density1.46
TSCAYes
Melting Point226-230°C
Solubility易溶于水和甲酸,微溶于乙醇,不溶于乙醚。
Stability对光及湿度敏感
Appearance powder
Boiling Point235 °C at 760 mmHg

别名和识别编码

Chemical NameL-Arginine monohydrochloride
CAS Number1119-34-2
Synonym L-Arginine (hydrochloride) {LY} L-Arginine (hydrochloride) {} {LY} L-Arginine (hydrochloride) {} {} {LY} L-Arginine (hydrochloride) {} {} {} {LY} L-Arginine (hydrochloride) {} {} {} {} {LY} L-Arginine (hydrochloride) {} {} {} {} {} {LY} L-Arginine (hydrochloride) {} {} {} {} {} {} {LY} L-Arginine (hydrochloride) {} {} {} {} {} {} {} {LY} L-Arginine (hydrochloride) {} {} {} {} {} {} {} {} {LY} L-Arginine (hydrochloride) {} {} {} {} {} {} {} {} {} {LY} L-Arginine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Arginine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {LY} L-Arginine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Arginine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Arginine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Arginine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID66250
EC Number214-275-1
Beilstein Registry Number3631658
MDL NumberMFCD00064550
Reaxys-RN3631658
Merck Number780
Chemical Name TranslationL-精氨酸单盐酸盐
Wiswesser Line NotationMUYZM3YZVQ &GH
LabNetwork Molecule IDLN00191844
InChIInChI=1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1
Canonical SMILESN[C@@H](CCCNC(N)=N)C(O)=O.[H]Cl
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分类

  • {SNA} Amino Acids, Analytical/Chromatography, Biochemicals and Reagents, Pharmacopoeia, Pharmacopoeia A-Z, Pharmacopoeial Amino Acids
  • {SNA} Amino Acids, Analytical Standards, Analytical/Chromatography, Certified Reference Materials (CRMs), Fluka CRM for chromatography (neats), Organic CRMs Alphabetical, Organic CRMs TraceCERT
  • {SNA} Amino Acid Standards, Amino Acid, Peptide & Protein Standards, Analytical Standards, 分析/色谱
  • {SNA} Amino Acid Standards,
  • {SNA} Analytical Standards,
  • {
  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards A - B, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
  • {SNA} Amino Acids,

产品应用

  • 一氧化氮合成酶底物,能转换为瓜氨酸和NO。靠一种依赖于NO的机制诱导胰岛素分泌。

相关文献及参考

  • [2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12.
  • [3]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17.
  • Borders, C.L., et al.: Protein. Sci., 3, 541 (1994),
  • Jones, et al.: Adv. Enzyme Regul., 9, 19 (1970),
  • Merck 14 ,780
  • Merck:14,780
  • Miura, T., et al.: Anal. Biochem., 139, 432 (1984),
  • Short: EINECS
  • Short: III/10a
  • Short: III/5a
  • [1]. Tapiero H, et al.
  • [1]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45.

安全信息

GHS Symbol
WGK Germany2
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves Eyeshields, Gloves
RTECSCF1995500
Precautionary statements
  • P305+P351+P338
Signal word Warning
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture Hygroscopic {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away f
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Risk Statements
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R37 Irritating to respiratory system 刺激呼吸道
Hazard Codes Xi
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3793 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   ABBIA4 Archives of Biochemistry and Biophysics.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.31-    1951-  Volume(issue)/page/year:
   58,253,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 12 gm/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 62,49,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 90 mg/kg
SEX/DURATION            : female 1-6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   AJEBAK Australian Journal of Experimental Biology and Medical Science.
   (Adelaide, S.A., Australia) V.1-64, 1924-86.  Volume(issue)/page/year:
   51,553,1973

其他信息

  • 上游原料:盐酸 --> 活性炭 --> 明胶 --> L-精氨酸
  • {
  • 毒性分级:中毒
  • 外观:白色结晶体或结晶粉末,有特殊的酸味。
  • 用途二:营养增补剂。
  • 灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
  • 类别:有毒物品
  • 用途三:该品为氨基酸类药物。服用后可参与鸟氨酸循环,促进血内氨通过鸟氨酸循环转变成无毒的尿素,从而降低血氨。但
  • 用途四:L-精氨酸盐酸盐(1119-34-2)的有效成份为L-精氨酸,用于医药可帮助伤口愈合,刺激免疫系统的发展,提升荷尔蒙的分泌,促进尿循环,降低血液中氨的含量,治疗血氨中毒。对急性病毒性肝炎,慢性持续性肝炎以及肝硬化也有较好的治疗效果,并可防止和治疗脂肪肝病变,起到有效的护肝作用。
  • L-精氨酸盐酸盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 62004232 L-精氨酸盐酸盐;L-盐酸蛋白氨基酸;L-盐酸胍基戊氨酸;盐酸L-精氨酸 5g 8.2元 2011/04/16 A0528 L-(+)-精氨酸单盐酸盐 L-(+)-Arginine Hydrochloride 25G 142元 2011/04/16 A0528 L-(+)-精氨酸单盐酸盐 L-(+)-Arg
  • 使用限量:占食品中总蛋白质量的6.6%(FDA§172.320,2000)。
  • Alfa Aesar:L-精氨酸单盐酸盐,98+% L-Argini
  • 参考质量标准:FCC,1996 含量(以干基计) 98.5%~101.5% 重金属(以Pb计,GT-16-12) ≤0.002% 铅(GT-18) ≤10mg/kg 干燥失重(105℃,2h) ≤0.3% 灼烧残渣(GT-27) ≤0.1% 比旋光度[α] D 20 +21.3°~+23.5°(干燥后) [α] D 25 +21.2°~+2
  • FEMA:3819
  • 含量分析:精确称取试样约200mg,移入一250ml烧瓶,加3ml甲酸和50ml冰醋酸使之溶解。加醋酸汞试液(TS-137)l0ml和结晶紫试液(TS-74)2滴,用0.1mol/L高氯酸滴定至开始出现纯绿色,或至蓝色完全消失。每Ml 0.1rnol/L高氯酸相当于L-精氨酸盐酸盐(C6H14N4O2?HCl)10.53mg。
  • 毒性:可安全用于食品(FDA§172.320,2000)。 LD 50 12g/kg(大鼠,经口)。
  • 用途五:一氧化氮合成酶底物,能转换为瓜氨酸和NO。靠一种依赖于NO的机制诱导胰岛素分泌。
  • 可燃性危险特性:可燃; 燃烧产生有毒氮氧化物和氯化氢烟雾
  • 储运特性:库房通风低温干燥
  • Acros Organics:L(+)-精氨酸盐酸盐 L(+)-Arginine hydrochloride, 98+%(1119-34-2)
  • F:3-10
  • 鉴别试验:取0.1%试样液5ml,加水合茚三酮试液(TS-250)lml,共热,应呈红紫色。 0.1%试样液的氯化物试验(IT-12)应呈阴性。
  • 图谱信息:L-精氨酸盐酸盐(1119-34-2)质谱(MS) L-精氨酸盐酸盐(1119-34-2)核磁图( 13 CNMR) L-精氨酸盐酸盐(1119-34-2)红外图谱(IR1) L-精氨酸盐酸盐(1119-34-2)核磁图( 1 HNMR)
  • 用途一:用作医药原料及食品添加剂
  • 检测方法:T,NMR
  • TCI Shanghai:L-精氨酸单盐酸盐 L-(+)-Arginine Hydrochloride,>;98.0%(T)(1119-34-2)
  • 比旋光度:22 ° (c=8,6N HCl)
  • MOL 文件:1119-34-2.mol
  • Sigma Aldrich:1119-34-2(sigmaaldrich)
  • {Chemical

系列性分类


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