(+/-)-2,5-DIMETHOXY-4-BROMO-AMPHETAMINE HYDROBROMIDE
CAS 53581-53-6 MFCD00069251
化学结构图
SMILES: Br.COC1=CC(CC(C)N)=C(C=C1Br)OC
化学属性
| Mol. Formula | C11H16BrNO2.BrH |
|---|---|
| Mol. Weight | 355.11 |
别名和识别编码
| Chemical Name | Phenethylamine, 4-bromo-2,5-dimethoxy-alpha-methyl-,hydrobromide, DL- |
|---|---|
| Synonym | DL-4-Bromo-2,5-dimethoxyamphetamine hydrobromide dl-2,5-Dimethoxy-4-bromoamphetamine hydrobromide DOB (±)-DOB hydrobromide DL-4-Bromo-2,5-dimethoxy-alpha-methylphenethylamine hydrobromide |
| MDL Number | MFCD00069251 |
| PubChem Substance ID | 24894134 |
| CAS Number | 53581-53-6 |
| Wiswesser Line Notation | ZY1&1R DE BO1 EO1 &EH |
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分类
- Agonists, Alphabetic, Amphetamine, Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure, Chromatography, D, DID - DIN, DIG-DY, Drugs & Metabolites, Drugs of Abuse, Forensic and Veterinary Standards, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neat Compounds, Neuroscience, Neurotransmission, Neurotransmission (Obesity), Neurotransmitters,
相关文献及参考
- Arvanov, et al., LSD and DOB: interaction with 5-HT2A receptors to inhibit NMDA receptor-mediated transmission in the rat prefrontal cortex. Eur. J. Neurosci. 11 , 3064, (1999) 摘要
- Titeler, et al., Selectivity of serotonergic drugs for multiple brain serotonin receptors. Role of [ 3 H]-4-bromo-2,5-dimethoxyphenylisopropylamine ([ 3 H]DOB), a 5-HT 2 agonist radioligand. Biochem. Pharmacol. 36 , 3265, (1987) 摘要
- Heller, et al., Potent agonist activity of DOB at 5-HT 2 receptors in guinea pig trachea. Eur. J. Pharmacol. 138 , 115, (1987) 摘要
安全信息
GHS Symbol
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P302+P350
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- H330 Fatal if inhaled 吸入致命
- H310 Fatal in contact with skin 皮肤接触致命
- H302 Harmful if swallowed 吞食有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 6400 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 45,49,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 45,49,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Skin and Appendages - hai
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >400 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - changes in motor activity (specific assay) Skin and Appendages - hair REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 45,49,1978
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