(4Ar,6R,7R,7As)-6-(6-Amino-9H-Purin-9-Yl)-2,7-Dihydroxytetrahydro-4H-Furo[3,2-D][1,3,2]Dioxaphosphinine2-Oxide,SodiumSalt (4aR,6R,7R,7aS)-6-(6-氨基-9H-嘌呤-9-基)-2,7-二羟基四氢-4H-呋喃[3,2-d][1,3,2]二氧杂膦2-氧化物钠盐

CAS 37839-81-9 MFCD00069736

化学结构图

37839-81-9
SMILES: [Na+].NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]1O |&1:11,13,20,21|

化学属性

Mol. FormulaC10H11N5O6PNa
Mol. Weight369
TSCANo

别名和识别编码

Chemical Name(4Ar,6R,7R,7As)-6-(6-Amino-9H-Purin-9-Yl)-2,7-Dihydroxytetrahydro-4H-Furo[3,2-D][1,3,2]Dioxaphosphinine2-Oxide,SodiumSalt
Synonym 3',5'-Amp sodium salt 3,5-Cyclic AMP sodium salt 3′,5′-Cyclic AMP sodium salt Adenosine 3',5'-cyclic monophosphate sodium salt monohydrate Cyclic 3',5'-(hydrogen phosphate)adenosine monosodium salt Cyclic 3',5'-amp sodium salt cAMP-Na 环化腺苷酸 钠盐 腺苷-3′,5′-环单磷酸 钠盐 一水合物
MDL NumberMFCD00069736
PubChem Substance ID87560483
Beilstein Registry Number5215289
CAS Number37839-81-9
Reaxys-RN5215289
Chemical Name Translation(4aR,6R,7R,7aS)-6-(6-氨基-9H-嘌呤-9-基)-2,7-二羟基四氢-4H-呋喃[3,2-d][1,3,2]二氧杂膦2-氧化物钠盐
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} A-AM, Bioactive Small Molecule Alphabetical Index, Cyclic Nucleotide Metabolism, Cyclic Nucleotides and Analogs, G Proteins and Cyclic Nucleotides, Kinase/Phosphatase Biology, Nucleotide, Protein Kinase A (PKA), Serine/Threonine Kinase Activators, Serine/Threonine Kinase Biology, 代谢组学, 代谢通路, 代谢通路图中的代谢产物和辅酶分子, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} A-AM, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Nucleosides, Nucleotides, Oligonucleotides, Nucleotides
  • A-AM, Bioactive Small Molecules, Cell Biology, Cell Signaling and

相关文献及参考

  • Giusti, C., et al., Necrotic Cell Death: From Reversible Mitochondrial Uncoupling To Irreversible Lysosomal Permeabilization. Exp. Cell Res. 315 , 26-38, (2009) 摘要
  • Dreier, B., and Plückthun, A., Ribosome Display: A Technology For Selecting And Evolving Proteins From Large Libraries. Methods Mol. Biol. 687 , 283-306, (2011) 摘要
  • Tuganowski, W. and Kopeć, P., Effect of exogenous cAMP in the rabbit right auricle Pol. J. Pharmacol. Pharm. 30 , 451-4, (1978)
  • Dunzendorfer, U. and Knöner, M., Effect of high level bovine parathyroid extracts on serum PTH, cAMP and urinary cAMP, Na + , and uric acid in stone-forming patients Eur. Urol. 8 , 363-6, (1982)
  • Beese, M., et al., Effect of cAMP derivates on assembly and maintenance of tight junctions in human umbilical vein endothelial cells BMC Cell Biol. 11 , 68, (2010)
  • Daniel, P.B., et al., Cyclic AMP signaling and gene regulation. Annu. Rev. Nutr. 18 , 353-383, (1998)
  • Spada, A., et al., Cyclic AMP and calcium in the transduction of hypothalamic neurohormone action in human pituitary tumors. Horm. Res. 47 , 235-239, (1997) 摘要
  • Chen, T.C., et al., Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab. Invest. 78 , 165-174, (1998) 摘要

安全信息

WGK Germany2
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSAU7357900 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 14300 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - other changes
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 1(2),15,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 645 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 1(2),15,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 395 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 1(2),15,1976

GHS Symbol
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleotides - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Synthetic Oligonucleotides and Related Reagents - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. A-AM - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. G Proteins and Cyclic Nucleotides - Cell Signaling and Neuroscience
  5. Cyclic Nucleotide Metabolism - G Proteins and Cyclic Nucleotides
  6. Cyclic Nucleotides and Analogs - Cyclic Nucleotide Metabolism
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. G Proteins and Cyclic Nucleotides - Cell Signaling and Neuroscience
  5. Cyclic Nucleotide Metabolism - G Proteins and Cyclic Nucleotides
  6. Cyclic Nucleotides and Analogs - Cyclic Nucleotide Metabolism

相关产品推荐