• H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
• H317 May cause an allergic skin reaction 可能导致皮肤过敏
• H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难

• P342+P311
• P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
• P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
• P304+P340
• P284 Wear respiratory protection.? 佩戴呼吸保护装置。
• P308+P313
• P201 Obtain special instructions before use. 使用前获取专门指示。

• S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
• S36 Wear suitable protective clothing 穿戴适当的防护服；
• S24 Avoid contact with skin 避免皮肤接触；
• S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
• S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
• S37 Wear suitable gloves 戴适当手套；
• S22 Do not breathe dust 不要吸入粉尘；

• R42/43
• R63 Possible risk of harm to the unborn child 可能危害未出生婴儿

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 5385 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JOBAAY Journal of Bacteriology.  (American Soc. for Microbiology, 1913 I
   St., NW, Washington, DC 20006)  V.1-    1916-  Volume(issue)/page/year:
   32,227,1936

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 41500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 30,759,1980

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Intravenous
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 400 ug/kg
REFERENCE :
   JJMCAQ Japanese Journal of Medical Science and Biology.  (National Institute
   of Health, 2-chome, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.5-    1952-
    Volume(issue)/page/year: 36,43,1983

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Non-mammalian species Embryo
DOSE/DURATION           : 25 mg/L
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 32,1568,1976

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Insect - not otherwise specified Embryo
DOSE/DURATION           : 100 mg/L
REFERENCE :
   DKBSAS Doklady Biological Sciences (English Translation).  Translation of
   DANKAS: Biological Section. (Plenum Pub. Corp., 233 Spring St., New York, NY
   10013)  V.112-    1957-  Volume(issue)/page/year: 223,316,1975

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 1 mg/L
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 65,1321,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   34,701,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   CGANE7 Congenital Anomalies.  (Nippon Senten Ijo Gakkai, 377-2 Ono-higashi,
   Osakasayama, Osaka-Fu 589 Japan)  V.27-    1987-  Volume(issue)/page/year:
   34,113,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 5 mg/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - cytological changes (including
   somatic cell genetic material)
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   NDKIA2 Kankyo Igaku Kenkyusho Nenpo (Nagoya Daigaku).  Annual Report of the
   Research Institute of Environmental Medicine, Nagoya University.  (Nagoya
   Daigaku Kankyo Igaku Kenkyusho, Furo-cho, Chikosa-ku, Nagoya 464, Japan)
   V.1-    1949-  Volume(issue)/page/year: 32,230,1981

TYPE OF TEST