Cefaclor Monohydrate 头孢克洛一水合物

CAS 70356-03-5 MFCD00071999

化学结构图

70356-03-5
SMILES: O.N[C@H](C1C=CC=CC=1)C(=O)N[C@H]1[C@H]2SCC(Cl)=C(C(O)=O)N2C1=O

化学属性

Mol. FormulaC15H14ClN3O4S.H2O
Mol. Weight385.85

别名和识别编码

Chemical NameCefaclor Monohydrate
CAS Number70356-03-5
Synonym Lilly 99638 hydrate Panoral hydrate Raniclor Ceclor Keflor Distaclor (6R,7R)-7-[(2-Amino-2-phenylacetyl)amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Monohydrate Cefaclor hydrate
Chemical Name Translation头孢克洛一水合物
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分类

  • Chiral Reagents
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds,

产品应用

  • Second-generation cephalosporin antibiotic. Antibacterial.

相关文献及参考

  • Gray, B.M., et al.: Antimicrob. Agents Chemother., 13, 988 (1978),
  • Lorenz, L.J., et al.: Anal. Profiles Drug Subs., 9, 107 (1980),
  • Hori, R., et al.: J. Pharm. Pharmacol., 40, 646 (1988),

安全信息

RTECSXI0365000 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
REFERENCE :
   PMESAJ Postgraduate Medical Journal, Supplement.  (Blackwell Scientific Pub.
   Ltd., POB 88, Oxford, UK)  V.1-    1949-  Volume(issue)/page/year: 55(Suppl
   4),17,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1227 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 13,637,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4838 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 13,637,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >20 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 13,637,1982

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系列性分类

  1. Functional Group 官能团索引
  2. hemithioaminal

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