(R)-(−)-Epichlorohydrin (R)-(-)-环氧氯丙烷

CAS 51594-55-9 MFCD00077759

化学结构图

51594-55-9
SMILES: ClC[C@@H]1CO1

化学属性

Mol. FormulaC3
Mol. Weight93
Refractive index1.4360 to 1.4400
Boiling Point114
Density1.18
Flash Point31°C(lit.)
TSCAYes
Autoignition Point772 °F
Vapor Density3.29 (vs air)
Vapor Pressure10 mmHg ( 16.6 °C)
Melting Point-25.6°C

别名和识别编码

Chemical Name(R)-(−)-Epichlorohydrin
CAS Number51594-55-9
Synonym (R)-(-)-Epichlorohydrin (2R)-(Chloromethyl)oxirane (R)-(-)-1-Chloro-2,3-epoxypropane (-)-Epichlorohydrin (R)-(-)-环氧氯丙烷 (2R)-2-(Chloromethyl)oxirane (R)-(-)-2-(氯甲基)环氧乙烷 (R)-Epichlorohydrin (R)-(Chloromethyl)oxirane (-)-2-(Chloromethyl)oxirane (R)-1-Chloro-2, (R)-(−)-环氧氯丙烷 表氯醇
Beilstein Registry Number1420785
PubChem Substance ID87569819
EC Number424-280-2
MDL NumberMFCD00077759
Reaxys-RN1420785
Merck Number3532
Alfabeta NameCHLOROMETHYLOXIRANE R22(())--
Chemical Name Translation(R)-(-)-环氧氯丙烷
LabNetwork Molecule IDLN00183490
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分类

  • Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Epoxides, Organic Building Blocks
  • {SNA} Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Epoxides, Organic Building Blocks

产品应用

  • 用在合成手性吗啉和二噁烷。

相关文献及参考

  • Romano, K.P. et al.: Chem. Res. Toxicol., 20, 832 (2007); Smyth, H.F., et al.: J. Ind. Hyg. Toxicol., 30, 63 (1948);
  • Synlett , 2151, (2006)
  • Beilstein:17(5)1,20
  • Beil. 17 ,V,1,20

安全信息

GHS Symbol
WGK Germany3
Hazard Codes 6.1 T
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H301 Toxic if swallowed 吞食有毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H331 Toxic if inhaled 吸入中毒
  • H350 May cause cancer 可能致癌
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSRR0427000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241+P242+P243
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P301+P330+P331+P310
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P308+P311
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
UN Number 2023 UN2023
Risk Statements
  • R10 Flammable 易燃
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R45 May cause cancer 可能致癌
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
Packing GroupII
Warnings IRRITANT
Hazard Class6.1/3
Storage condition 储存温度 2-8℃
TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 298,197,1993

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 800 nmol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 298,197,1993

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 298,197,1993

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 298,197,1993

其他信息

  • 有类似氯仿的气味。易挥发。不稳定。能与乙醇、乙醚、氯仿、三氯乙烯和四氯化碳等混溶,不溶于水。

系列性分类


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