Carbinoxamine Maleate (2-((4-氯苯基)(2-吡啶基)甲氧基)乙基)-N,N-二甲基胺马来酸盐

CAS 3505-38-2 MFCD00082461

化学结构图

3505-38-2
SMILES: CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O

化学属性

Mol. FormulaC20H23ClN2O5
Mol. Weight407
Melting Point116.0 to 121.0 deg-C

别名和识别编码

Chemical NameCarbinoxamine Maleate
CAS Number3505-38-2
Synonym Clistine maleate p-Carbinoxamine maleate Ethanamine, 2-((4-chlorophenyl)-2-pyridinylmethoxy)-N,N-dimethyl-, 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridinebimaleate 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)-pyridinmaleate(1:1) 2-[(4-Clorophenyl)-2-pyridinylmethoxy]-N,N-dimethyl-ethanamine Maleate Salt Clistin maleate Allergefon maleate 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine bimaleate clistinmaleate CARBINOXAMINE MALEATE Allergefon 马来酸罗托沙敏 Carbinoxamine maleate salt; N-[2-[(4-Chlorophenyl)(2-pyridinyl)methoxy]ethyl]-N,N-dimethylamine maleate salt N-[2-[(4-Chlorophenyl)(2-pyridinyl)methoxy]ethyl]-N,N-dimethylamine maleate salt allergefonmaleate ciberon 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-n,n-dimethyl-ethanamin(z)-2-butene p-carbinoxaminemaleate clistinemaleate 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine maleate Clistin CARBINOXAMINE MALEATE SALT N-[2-[(4-氯苯基)(2-吡啶基)甲氧基]乙基]-N,N-二甲基胺马来酸盐 马来酸卡比沙明 hislosine 2-[(4-Clorophenyl)-2-pyridinylmethoxy]-N,N-dimethylethanamine Maleate Salt 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridinemaleate 2-((4-chlorophenyl)-2-pyridinylmethoxy)-n,n-dimethyl-ethanamin(z)-2-bute carbinoxamine hydrogen maleate 卡比沙明 马来酸盐 Carbinoxamine maleate Ciberon clistin lergefin
MDL NumberMFCD00082461
PubChem Substance ID5282409
EC Number222-498-0
Chemical Name Translation(2-((4-氯苯基)(2-吡啶基)甲氧基)乙基)-N,N-二甲基胺马来酸盐
Reaxys-RN6557352
Merck Number1799
Wiswesser Line NotationQV1U1VQ -C &621
LabNetwork Molecule IDLN01273671
InChIInChI=1S/C16H19ClN2O.C4H4O4/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-10,16H,11-12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
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分类

  • {SNA} Analytical Standards, Antihistamines Standards, Pharmaceuticals, Illicit Drugs & Alcohol, 分析/色谱
  • Heterocycles
  • Pharmaceuticals
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, C, CA - CG
  • {SA} Alphabetic, Analytical Standards, Analytical/Chromatography, C, CA - CG, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds
  • Aromatics
  • Intermediates & Fine Chemicals,

产品应用

  • Analgesic and anti-inflammatory compound.

相关文献及参考

  • Cochin, J., et al.: J. Pharmacol. Exp. Ther., 139, 160 (1963),
  • [1]. Harikrishnan A, et al. The cooperative effect of Lewis pairs in the Friedel-Crafts hydroxyalkylation reaction: a simple and effective route for the synthesis of (±)-carbinoxamine. Org Biomol Chem. 2015 Mar 28;13(12):3633-47.

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P301+P310+P330
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+P310
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P405 Store locked up. 上锁保管。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSUS6350000
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Hazard Codes T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Packing GroupIII
Hazard Class6.1
UN Number 3249 2811 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOIZAG Toho Igakkai Zasshi.  Journal of Medical Society of Toho University.
   (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
   Japan)  V.1-    1954-  Volume(issue)/page/year: 15,367,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 411 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)

{

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 1880 ug/kg/4D-I
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - excitement
REFERENCE :
   JTCTDW Journal of Toxicology, Clinical Toxicology.  (Marcel Dekker, 270
   Madison Ave., New York, NY 10016)  V.19-    1982-  Volume(issue)/page/year:
   25,161,1987

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 36 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)

TYPE OF

TYPE OF TEST            : LD50

其他信息

  • MOL 文件:3505-38-2.mol
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 类别:有毒物质
  • 毒性分级:高毒
  • 可燃性危险特性:可燃; 火场释放有毒氮氧化物, 氯化物烟雾
  • 灭火剂:水, 二氧化碳, 泡沫, 沙土
  • Sigma Aldrich:3505-38-2(sigmaaldrich)
  • 急性毒性:口服- 小鼠 LD50: 162 毫克/ 公斤; 皮下- 小鼠 LD50: 350 毫克/ 公斤

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs & Metabolites - Forensic and Veterinary Standards
  6. Neat Compounds - Drugs & Metabolites
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. C - Alphabetic
  5. CA - CG - C
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Histamine Receptor  (组胺受体)

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