艾菲地可宁, 来源于黑曲霉 艾菲地可宁, 来源于黑曲霉

CAS 38966-21-1 MFCD00083214

化学结构图

38966-21-1
SMILES: C[C@]12CC[C@@H](O)[C@@](C)(CO)[C@@H]1CC[C@H]1C[C@@H]3C[C@]21CC[C@]3(O)CO

化学属性

Mol. FormulaC20H34O4
Mol. Weight338
Melting Point227-233 °C(lit.)

别名和识别编码

Chemical NameAphidicolin from Nigrospora sphaerica
Synonym Aphidicolin ICI 69653 APC NSC-234714
MDL NumberMFCD00083214
PubChem Substance ID24890452
Beilstein Registry Number4689958
CAS Number38966-21-1
Chemical Name Translation艾菲地可宁, 来源于黑曲霉
Wiswesser Line NotationL C6 B656 A 1B P BXTJ C1 FQ G1Q NQ N1Q
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分类

  • {SNA} AN-AZ, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Antiparasitic / Antiprotozoal / Anthelminthic, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Interferes with DNA Synthesis, Mechanism of Action, Spectrum of Activity, 抗生素, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Analytical Standards, Analytical/Chromatography, Antibiotics, Chemical Structure, Chromatography, Clinical Standards,

相关文献及参考

  • Spadari, S., et al., Control of cell division by aphidicolin without adverse effects upon resting cells. Arzneimittelforschung 35 , 1108-1116, (1985) 摘要
  • Yamada, K., and Itoh, R., Involvement of DNA polymerase delta and/or epsilon in joining UV-induced DNA single strand breaks in human fibroblasts. Biochim. Biophys. Acta 1219 , 302-306, (1994) 摘要
  • Cheng, C.H., and Kuchta, R.D., DNA polymerase epsilon: aphidicolin inhibition and the relationship between polymerase and exonuclease activity. Biochemistry 32 , 8568-8574, (1993) 摘要
  • Mutomba, M.C., and Wang, C.C., Effects of aphidicolin and hydroxyurea on the cell cycle and differentiation of Trypanosoma brucei bloodstream forms. Mol. Biochem. Parasitol. 80 , 89-102, (1996) 摘要
  • Kuwakado, K., et al., Augmentation by aphidicolin of 1-β-D-arabinofuranosylcytosine-induced c-jun and NF-kappa B activation in a human myeloid leukemia cell line: correlation with apoptosis. Leuk. Res. 19 , 645, (1995) 摘要
  • Wang, N.D., et al., Determination of the specificity of aphidicolin-induced breakage of the human 3p14.2 fragile site. Genomics 17 , 341-347, (1993) 摘要
  • McAllister, B.F., and Greenbaum, I.F., How common are common fragile sites: variation of aphidicolin-induced chromosomal fragile sites in a population of the deer mouse ( Peromyscus maniculatus ). Hum. Genet. 100 , 182-188, (1997) 摘要
  • Humphries MJ, Limesand KH, Schneider JC, Nakayama KI, Anderson SM, Reyland ME, Suppression of apoptosis in the protein kinase Cdelta null mouse in vivo. J. Biol. Chem. , 9728-37, (2005)
  • Isaac CE, et. al., The retinoblastoma protein regulates pericentric heterochromatin. Mol. Cell. Biol. , 3659-71, (2006) 摘要
  • Rowe, J., et al., Compounds That Target Host Cell Proteins Prevent Varicella-zoster Virus Replication

安全信息

RTECSPB9185000
WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
GHS Symbol
TYPE OF TEST            : DNA inhibition

{h

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 1 mg/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   51,1829,1991

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Mammal - species unspecified Fibroblast
DOSE/DURATION           : 1 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 160,103,1986

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 500 ug/L
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 18,50,1980

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 14 nmol/L
REFERENCE :
   ENVRAL Environmental Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-    1967-  Volume(issue)/page/year: 49,79,1989

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 50 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 144,257,1985

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Mammal - species unspecified Cells - not otherwise
                          specified
DOSE/DURATION           : 1 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Nethe

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