Brefeldin A 布雷非德菌素 A

CAS 20350-15-6 MFCD00083258

化学结构图

20350-15-6
SMILES: C[C@H]1CCCC=C[C@@H]2C[C@H](O)C[C@H]2[C@H](O)C=CC(=O)O1

化学属性

Mol. FormulaC16
Mol. Weight280
Flash Point87 ºC
Melting Point204-205

别名和识别编码

Chemical NameBrefeldin A
CAS Number20350-15-6
Synonym Cyanein NSC 244390 Decumbin Ascotoxin ?-4-Dihdyroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic Acid, ?-Lactone, BFA, Cyanein, Ascotoxin, Decumbin Cyanaein Brefeldin A Nectrolide γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid NSC 56310 1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent [f]oxacyclotridecin-4-one; Ascotoxin; Cyanein (+)-Brefeldin A
MDL NumberMFCD00083258
InChIKeyKQNZDYYTLMIZCT-KQPMLPITSA-N
Chemical Name Translation布雷非德菌素 A
Wiswesser Line NotationT5-13- IVO GU OUTJ CQ FQ K1
Beilstein Registry Number25191
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分类

  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • A macrolide isolated from Penicillium brefeldianum. It affects the vesticular transport of the Golgi apparatus and induces DNA fragmentation which leads to apoptosis.

相关文献及参考

  • Misumi, Y., et al.: J. Biol. Chem., 261 (1986),
  • Mordente, J.A., et al.: J. Urol., 159, 275 (1998),
  • Erokhina, M.V., et al.: Membr. Cell Biol., 12, 871 (1999),

安全信息

Safety Statements
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
RTECSGY8410000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJANAX Japanese Journal of Antibiotics.  (Japan Antibiotics Research Assoc.,
   2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)  V.21-    1968-
   Volume(issue)/page/year: 34,51,1981

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 200 ug/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 39,1148,1986

GHS Symbol
UN Number
Hazard Codes
Signal word
WGK Germany3
Precautionary statements
Packing GroupIII

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics A-F - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Spectrum of Activity - Antibiotics
  4. Antibacterial - Spectrum of Activity
  5. A - K - Antibacterial
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Apoptosis Inducers - Apoptosis and Cell Cycle
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Antibiotics by Application
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Chemical Structure Class
  5. Indol Derivatives
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Mechanism of Action
  5. Interferes with DNA Synthesis
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Spectrum of Activity
  5. Antibacterial

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