5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM SALT
CAS 148892-91-5 MFCD00084770
化学结构图
SMILES: [Na+].[Na+].[Na+].NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)NP([O-])(O)=O)[C@@H](O)[C@H]2O)C(O)=N1
化学属性
| Mol. Formula | C10H14N6Na3O13P3· xH2O |
|---|---|
| Mol. Weight | 588.14 (anhydrous basis) |
别名和识别编码
| Chemical Name | Guanosine 5'-[β,γ-imido]triphosphate trisodium salt hydrate |
|---|---|
| Synonym | β:γ-Imidoguanosine 5′-triphosphate trisodium salt hydrate β:γ-Imidoguanosine 5′-triphosphate trisodium salt hydrate 5′-Guanylyl-imidodiphosphate trisodium salt hydrate GMP-PNP Gpp(NH)p 5′-Guanylyl-imidodiphosphate trisodium salt hydrate 5'-Guanylyl-imidodiphosphate trisodium salt hydrate GMP-PNP Gpp(NH)p β:γ-Imidoguanosine 5'-triphosphate trisodium salt hydrate β:γ-Imidoguanosine 5'-triphosphate trisodium salt hydrate 5'-Guanylyl-imidodiphosphate trisodium salt hydrate GMP-PNP Gpp(NH)p |
| CAS Number | 148892-91-5 |
| PubChem Substance ID | 329757664 |
| MDL Number | MFCD00084770 |
| Chemical Name Translation |
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分类
- Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cofactors, Core Bioreagents, Enzymes, Inhibitors, and Substrates, G, G Protein Function, G Proteins and Cyclic Nucleotides, Nucleosides and Nucleotides, Phosphate Donors, Reagents,
- {SNA} Cofactors, Core Bioreagents, G Protein Function, G Proteins and Cyclic Nucleotides, Nucleosides and Nucleotides, Phosphate Donors, Reagents, Research Essentials, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
相关文献及参考
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- 2. Miller, J.D., and Walter, P., A GTPase cycle in initiation of protein translocation across the endoplasmic reticulum membrane. Ciba Found. Symp. 176 , 147-163, (1993) 摘要
- 3. Connolly, T., et al., Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor. Science 252 , 1171-1173, (1991) 摘要
- Gill, D.M., and Woolkalis, M.J., Cholera toxin-catalyzed [32P]ADP-ribosylation of proteins. Meth. Enzymol. 195 , 267-280, (1991) 摘要
- Bellodi, C., et al., Loss Of Function Of The Tumor Suppressor DKC1 Perturbs P27 Translation Control And Contributes To Pituitary Tumorigenesis. Cancer Res. 70 , 6026-35, (2010) 摘要
- Gurdal H, Friedman E, et al., Decrease in apparent α1-adrenoceptor-G protein coupling during maturation in rat aorta. J. Gerontol. Biol. Med. Sci. 53 , B268-B273, (1998)
- Ye M, Shima F, Muraoka S, et al., Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases. J. Biol. Chem. 280 , 31267-31275, (2005)
- Yatime L, Mechulam Y, et al., Structural switch of the γ subunit in an archaeal aIF2 α γ heterodimer. Structure 14 , 119-128, (2006)
- Rambotti MG, Mariucci G, et al., Ultracytochemical demonstration of soluble guanylate cyclase activation in rat aorta by NCX4016, a NO-releasing aspirin derivative. J. Submicrosc. Cytol. Pathol. 38 , 149-154, (2006)
- Gullapalli S, Amrutkar D, Gupta S, et al., Characterization of active and inactive states of CB1 receptor and the differential binding state modulation by cannabinoid agonists, antagonists and inverse agonists. Neuropharmacology 58 , 1215-1219, (2010)
- Minuzzi L, Cum
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
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