Dichlorphenamide 4,5-二氯苯-1,3-二磺酰胺
CAS 120-97-8 MFCD00148948
化学结构图
SMILES: NS(=O)(=O)c1cc(Cl)c(Cl)c(S(N)(=O)=O)c1
化学属性
| Mol. Formula | C6H6Cl2N2O4S2 |
|---|---|
| Mol. Weight | 305 |
| Appearance | 白色或近白色结晶性粉末。熔点239-241℃。溶于乙醇，易溶于碱性溶液，几乎不溶于水或氯仿。无臭，味微苦。 |
| Solubility | DMSO 61 mg/mL Water <1 mg/mL Ethanol 33 mg/mL |
别名和识别编码
| Chemical Name | Dichlorphenamide |
|---|---|
| CAS Number | 120-97-8 |
| Synonym | 双氯非那胺 ######## 4,5-Dichloro-1,3-benzenedisulfonamide Antidrasi 双氯非那胺; 4,5-二氯苯-1,3-二磺酰胺 二氯磺胺 4,5-Dichlorobenzene-1,3-disulfonamide 4,5-dichloro-m-benzenedisulfonamid 4,5-DICHLORO-META-BENZENEDISULFONAMIDE Dasanide Oratrol DICHLORPHENAMIDE CB 8000 4,5-Dichloro-m-benzendisulfonamide 1,3-Disulfamyl-4,5-dichlorobenzene 3,4-Dichloro-5-sulfamylbenzenesulfonamide 4,5-Dichloro-1,3-disulfamoylbenzene 1,3-disulfamoyl-4,5-dichlorobenzene 1,3-Benzenedisulfonamide, 4,5-dichloro- Dichlorophenamide 4,5-二氯苯-1,3-二磺酰胺 4,5-Dichloro-m-benzenedisulfonamide 双氯磺酰胺 daramide 4,5-dichloro-m-benzenedisulfonamide 4,5-dichloro-3-benzenedisulfonamide LABOTEST-BB LT00771920 Dichlofenamide Daranide cb8000 Dichlorphenamide Diclofenamide;4,5-dichlorobenzene-1,3-disulfonamide 4,5-DICHLORO-BENZENE-1,3-DISULFONIC ACID DIAMIDE |
| EC Number | 204-440-6 |
| MDL Number | MFCD00148948 |
| Chemical Name Translation | 4,5-二氯苯-1,3-二磺酰胺 |
| Wiswesser Line Notation | ZSWR BG CG ESZW |
| Beilstein Registry Number | 2703329 |
| LabNetwork Molecule ID | LN01268499 |
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分类
- Aromatics
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Sulfur & Selenium Compounds
产品应用
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相关文献及参考
- [2]. Rucquoy, M. and L. Sorel, Diclofenamide in the treatment of therapy-resistant epilepsy. Acta Neurol Belg, 1978. 78(3): p. 174-82.
- Brzozowski, Z. et al.: Eur. J. Med. Chem., 46, 3656 (2010); Tawil, R. et al.: Ann. Neurol., 47, 46 (2000); Casey, J. et al.: J. Med. Chem., 47, 2337 (2004);
- [1]. Kanski, J.J., Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors. Br J Ophthalmol, 1968. 52(8): p. 642-3.
- [1]. Kanski, J.J., Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors. Br J Ophthalmol, 1968. 52(8): p. 642-3.
- [2]. Rucquoy, M. and L. Sorel, Diclofenamide in the treatment of therapy-resistant epilepsy. Acta Neurol Belg, 1978. 78(3): p. 174-82.
安全信息
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 304 mg/kg TOXIC EFFECTS : Details of toxic effects not reported o
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,41,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 643 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,41,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1244 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,446,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1710 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,41,1969
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - mouse DOSE : 144 mg/kg SEX/DURATION : female 13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - eye/ear REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 4,239,1971
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 4642 mg/kg SEX/DURATION : female 1-22 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 126,6,1967
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 500 mg/kg SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 11,31,1975
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE : 96 mg/kg SEX/DURATION : female 15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - eye/ear REFERENCE
其他信息
- 用途一:用作中间体
- 用途二:该品为碳酸酐酶的抑制药，具有降低眼内压、利尿作用。但利尿作用很弱，主要用于治疗青光眼以降低眼压。
- MOL 文件:120-97-8.mol
- Dichlorphenamide 是一种磺酰胺类碳酸酐酶抑制剂。
- 上游原料:邻二氯苯
- 方法一:由邻二氯苯经氯磺化、胺化而得。
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