L-Histidine hydrochloride hydrate L-组胺盐酸盐单水合物

CAS 5934-29-2 MFCD00151027

化学结构图

5934-29-2
SMILES: Cl.N[C@@H](Cc1c[nH]cn1)C(=O)O.O

化学属性

Mol. FormulaC6H12ClN3O3
Mol. Weight209.63
Density1.485
Melting Point254 °C
TSCAYes
Solubility169.9 G/L (20 ºC)
Appearance 属于准必需氨基酸(婴幼儿必需氨基酸)，在人体内合成较慢。如缺乏可导致发育迟缓、易生湿疹等症状。D-型与L-型生理效果相同。 白色晶体或结晶性粉末。无臭。稍有酸、苦味。约于250%：(干燥后)熔化并分解。性质稳定。水溶液呈酸性(pH值3.5～4.5)。易溶于水(39g/100ml,24℃)，在水中的溶解度远比L-组氨酸大。不溶于乙醇和乙醚。

别名和识别编码

Chemical NameL-Histidine Monohydrochloride Monohydrate
Synonym L-Histidine (hydrochloride hydrate) {LY} L-Histidine (hydrochloride hydrate) {} {LY} L-Histidine (hydrochloride hydrate) {} {} {LY} L-Histidine (hydrochloride hydrate) {} {} {} {LY} L-Histidine (hydrochloride hydrate) {} {} {} {} {LY} L-Histidine (hydrochloride hydrate) {} {} {} {} {} {LY} L-Histidine (hydrochloride hydrate) {} {} {} {} {} {} {LY} L-Histidine (hydrochloride hydrate) {} {} {} {} {} {} {} {LY} L-Histidine (hydrochloride hydrate) {} {} {} {} {} {} {} {} {LY} L-Histidine (hydrochloride hydrate) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} L-Histidine (hydrochloride hydrate) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Histidine (hydrochloride hydrate) {} {} {} {} {} {} {} {} {} {} {} {LY} L-Histidine (hydrochloride hydrate) {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Histidine (hydrochloride hydrate) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00151027
CAS Number5934-29-2
EC Number211-438-9
Beilstein Registry Number4168261
Merck Number4720
PubChem Substance ID165377
Reaxys-RN4168261
Chemical Name TranslationL-组胺盐酸盐单水合物
LabNetwork Molecule IDLN00188368
InChIInChI=1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1
Canonical SMILESO=C(O)[C@](N)([H])CC1=CN=CN1.Cl.O
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分类

  • {SNA} Amino Acids, BioUltra, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, H
  • {SNA} Amino Acids, BioUltra,
  • {SNA} Amino Acid Derivatives,
  • {SNA} Amino Acids, Bioactive Small Molecules,
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, H, Histaminergics,

产品应用

  • 组胺（histamine）的前体物质，依靠组氨酸脱羧酶（histidine decarboxylase）的催化

相关文献及参考

  • Short: III/20a
  • Short: III/31a
  • Short: III/10a
  • Merck:14,4720
  • Merck:14,4720 Beilstein:25,513

安全信息

Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
RTECSMS3119000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture Store at RT. {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed stora 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1677 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 97,1117,1977

其他信息

  • 方法一:由脱脂大豆水解物分离赖氨酸时的副产物。在碱性氨基酸中其碱性最弱，通过离子交换树脂柱，即能与其他碱性氨基酸分离。或使其形成难溶的汞盐、3，5-二氯苯磺酸盐等而分离。 由血红蛋白经用盐酸水解而得。 由发酵法制取。
  • 海关编码:29332990
  • L-盐酸组氨酸一水物价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 62014534 L-组氨酸盐酸盐 25g 26元 2011/04/16 H0150 L-组氨酸盐酸盐一水合物 L-Histidine Hydrochloride Monohydrate 25G 187元 2011/04/16 H0150 L-组氨酸盐酸盐一水合物 L-Histidine Hydrochloride Monohydrate 500G 1770元
  • Acros Organics:L-Histidine hydrochloride monohydrate, 98%(5934-29-2)
  • 比旋光度:9.9 ° (c=11, 6 N HCl)
  • MOL 文件:7048-02-4.mol
  • MOL 文件:5934-29-2.mol
  • Alfa Aesar:L-组氨酸盐酸盐单水合物,99% L-Histidine monohydrochloride monohydrate, 99%(5934-29-2)
  • TCI Shanghai:L-组氨酸盐酸盐一水合物 L-Histidine Hydrochloride Monohydrate,>;98.0%(T)(5934-29-2)
  • 图谱信息:L-组氨酸盐酸盐(7048-02-4)红外图谱(IR2) L-组氨酸盐酸盐(7048-02-4)核磁图( 1 HNMR) L-组氨酸盐酸盐(7048-02-4)红外图谱(IR1) L-组氨酸盐酸盐(7048-02-4)核磁图( 13 CNMR) L-组氨酸盐酸盐(7048-02-4)Raman光谱
  • F:10
  • 用途二:组织胺（histamine）的前体物质，依靠组氨酸脱羧酶（histidine decarboxylase）。
  • 上游原料:L-赖氨酸 --> 水解物 --> 大豆 --> 离子交换树脂柱 --> 血红蛋白
  • 无臭，稍苦酸味。易溶于甲酸，溶于水，不溶于乙醇和乙醚。 水中溶解度:169.9 g/l (20 C) [a]20/D: 9.9° (c=11, 6 N HCl)
  • Sigma Aldrich:5934-29-2(sigmaaldrich)
  • 用途一:用作生化试剂、医药原料及食品添加剂。
  • 用途一:营养增补剂。人体内合成速度较慢，为准必需氨基酸。可用于强化婴幼儿食品，外科手术后病人食品。用化学膨松剂制造面包时，添加组氨酸、亮氨酸、精氨酸可改善香味。
  • MSDS 信息:L-Histidine hydrochloride monohydrate(5934-29-2).msds

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Amino Acids 氨基酸
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Amino Acids 氨基酸
  4. BioUltra - Amino Acids
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. H - Bioactive Small Molecules
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Amino Acid Derivatives 氨基酸及其衍生物
  5. Histidine - Amino Acid Derivatives
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Amino Acid Derivatives 氨基酸及其衍生物
  5. Histidine - Amino Acid Derivatives
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Amino Acids and Vitamins
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Amino Acids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Albumins and Transport Proteins
  4. Albumin
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Culture
  4. Amino Acids and Vitamins
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Reagents and Supplements
  4. Amino Acids and Vitamins
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Culture
  4. Reagents and Supplements
  5. Amino Acids and Vitamins
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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