Rifampicin 利福平
CAS 13292-46-1 MFCD00151389
化学结构图
SMILES: CN1CCN(CC1)/N=C/c1c2NC(=O)C(C)=CC=C[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@H](C=CO[C@@]3(C)Oc4c(c(c(c2O)c(O)c4C)c1O)C3=O)OC |c:16,t:18,38|
化学属性
| Mol. Formula | C43H58N4O12 |
|---|---|
| Mol. Weight | 822.95 |
| Melting Point | 194 |
| Density | 1.34 |
别名和识别编码
| Chemical Name | Rifampicin |
|---|---|
| Synonym | Dione 21-acetate NSC 113926 Rifampicin SV Rimactan Rimactizid Rifaldazin 利福平 Rifampicinum Rifadin Rifaprodin Rifinah Rifagen Rifampicin 3-(4-甲基-1-哌嗪基亚胺甲基)利福霉素SV 甲哌利福霉素 R/AMP Rifampin 8-(4-Methylpiperazinyliminomethyl) rifamycin SV Rifadine Rifobac L-5103 3-(4-甲基-1-哌嗪基亚胺甲基)利福霉素SV 利米定 甲哌利福霉素 3-[[(4-methyl-1-piperazinyl)imino]methyl]-rifamycin Rifa {haz Riforal Rifamycin AMP 3-(4-Methylpiperazinyliminomethyl)-rifamycin SV Sinerdol 利米定 Rifoldine Rimactane Archidyn Rimactazid |
| CAS Number | 13292-46-1 |
| PubChem Substance ID | 87560354 |
| EC Number | 236-312-0 |
| Beilstein Registry Number | 5723476 |
| MDL Number | MFCD00151389 |
| Reaxys-RN | 5723476 |
| Merck Number | 8216 |
| Chemical Name Translation | 利福平 |
| InChIKey | JQXXHWHPUNPDRT-WLSIYKJHSA-N |
| Wiswesser Line Notation | T C6 B65-24- A D E 2BC G& AV LO NO F&VM OU B&U D&UMH&&&TJ DQ GQ IQ JI MI QO1 R1 SOV1 T1 UQ |
| LabNetwork Molecule ID | LN01374931 |
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分类
- {SNA} Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Chemical Structure Class, Core Bioreagents, Genetic Marker Selection, Life Science Reagents for Transfection, Macrolides,
产品应用
- 抑制DNA的重组和蛋白质插进成熟的病毒颗粒。靠结合RNA聚合酶的β-亚单元抑制RNA合成的起始。
相关文献及参考
- Su J, Yang X, Zheng T, Hong H., An efficient method to obtain axenic cultures of Alexandrium tamarense--a PSP-producing dinoflagellate. J. Microbiol. Methods 69 , 425-430, (2007) 摘要
- Nature 224 , 1280, (1969) 摘要
- Eberhard S, Drapier D, Wollman FA., Searching limiting steps in the expression of chloroplast-encoded proteins: relations between gene copy number, transcription, transcript abundance and translation rate in the chloroplast of Chlamydomonas reinhardtii. Plant J. 31 , 149-160, (2002) 摘要
- Wegrzyn, A., et al., Differential inhibition of transcription from sigma70- and sigma32-dependent promoters by rifampicin. FEBS Lett. 440 , 172-174, (1998) 摘要
- Merck: 14,8216
- Biochim. Biophys. Acta 157 , 215, (1968) 摘要
- Yuan L, Xu DQ., Stimulation effect of gibberellic acid short-term treatment on leaf photosynthesis related to the increase in Rubisco content in broad bean and soybean. Photosynth. Res. 68 , 39-47, (2001) 摘要
- Wehrli, W., Rifampin: mechanisms of action and resistance. Rev. Infect. Dis. 5 , S407-S411, (1983)
- Pfannschmidt, T., et al., The A and B forms of plastid DNA-dependent RNA polymerase from mustard ( Sinapis alba L. ) transcribe the same genes in a different developmental context. Mo
- Proc. Natl. Acad. Sci. U. S. A. 63 , 1327, (1969) 摘要
- Zicker AA, Kadakia CS, Herrin DL., Distinct roles for the 5' and 3' untranslated regions in the degradation and accumulation of chloroplast tufA mRNA: identification of an early intermediate in the in vivo degradation pathway. Plant Mol. Biol. 63 , 689-702, (2007) 摘要
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- P332+P313
- P302+P352+P332+P313+P362+P364
- P305+P351+P338+P337+P313
- P301+P312+P330
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 8400 mg/kg/60W-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Liver - tumors REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 43,293,1978
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 857 mg/kg TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Gastrointestinal - other changes Skin and Appendages - dermatitis, other (after systemic exposure) REFERENCE : JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 240,2283,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 504 mg/kg/42D-I TOXIC EFFECTS : Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea Blood - aplastic anemia REFERENCE : AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 87,459,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 416 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CMTRAG Chemotherapia. (Basel, Switzerland) V.1-12, 1960-67. For publisher information, see CHTHBK. Volume(issue)/page/year: 12,155,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 2120 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ACHTA6 Antibiotica et Chemotherapia (Basel, 1954-70). (Basel, Switzerland) V.1-16, 1954-70. For publisher information, see ANBCB3. Volume(issue)/page/year: 16,316,1970
TYPE OF TEST : DNA inhibition TEST SYSTEM : Human HeLa cell DOSE/DURATION : 250 mg/L REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Pu
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Human HeLa cell DOSE/DURATION : 250 mg/L REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 22,350,1984
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 10 ug/kg REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 194
TYPE OF TEST : DNA inhibition TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 100 mg/L REFERENCE : PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 79,1101,1982
TYPE OF TEST : Phage inhibition capacity TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 60 ng/plate REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,2819,1983
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 100 mg/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Vol
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 800 mg/kg SEX/DURATION : female 9-12 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : PRTUAX Problemy Tuberkuleza. Problems of Tuberculosis. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1923- Volume(issue)/page/year: 69(2),67,1991
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE : 2600 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) REFERENCE : ACHTA6 Antibiotica et Chemotherapia (Basel, 1954-70). (Basel, Switzerland) V.1-16, 1954-70. For publisher information, see ANBCB3. Volume(issue)/page/year: 16,316,1970
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 1400 mg/kg SEX/DURATION : female 4-10 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. (Paris, Franc
其他信息
- 溶解度: 1.3 mg/mL水 pH 4.3、2.5 mg/mL水 pH 7.3、100 mg/mL DMSO。
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