N-Benzyl-P-Toluenesulfonamide N-苄基对甲苯磺酰胺

CAS 1576-37-0 MFCD00159328

化学结构图

1576-37-0
SMILES: Cc1ccc(S(=O)(=O)NCc2ccccc2)cc1

化学属性

Mol. FormulaC14H15NO2S
Mol. Weight261.34
Melting Point113.0 to 117.0 deg-C
TSCANo

别名和识别编码

Chemical NameN-Benzyl-P-Toluenesulfonamide
CAS Number1576-37-0
Synonym N-BENZYL-4-METHYL-BENZENESULFONAMIDE N-Tosylbenzenemethaneamine N-Tosylphenylmethanamine N-Tosylbenzylamine N-苄基-对甲苯磺酸胺 NSC 37123 BTS N-Benzyl-p-toluenesulfonamide 4-METHYL-N-(PHENYLMETHYL)BENZENESULFONAMIDE N-Benzyl-p-tosylamide 4-Methyl-N-(phenylmethyl)benzenesulfonamide N-BENZYL-P-TOLUENESULPHONAMIDE Benzenesulfonamide, 4-methyl-N-(phenylmethyl)- 4-methyl-n-(phenylmethyl)-benzenesulfonamid n-benzyl-p-toluenesulfonamid N-Methyl-N-(phenylmethyl)benzenesulfonamide N-BENZYL-P-TOLUENESULFONAMIDE Benzyl(4-toluenesulfonyl)amine LABOTEST-BB LT00786416
MDL NumberMFCD00159328
Reaxys-RN2217277
Beilstein Registry Number12(3)2328
PubChem Substance ID95801
Chemical Name TranslationN-苄基对甲苯磺酰胺
InChIKeyWTHKAJZQYNKTCJ-UHFFFAOYSA-N
InChIInChI=1S/C14H15NO2S/c1-12-7-9-14(10-8-12)18(16,17)15-11-13-5-3-2-4-6-13/h2-10,15H,11H2,1H3
LabNetwork Molecule IDLN01272560
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分类

  • Inhibitors

产品应用

  • A potent inhibitor of skeletal muscle Ca2+-stimulated myosin S1 ATPase (IC50 approx. 5uM) activity. Reversible blocks the gliding motility. Also weakens myosin?s interaction with F-actin. Does not

相关文献及参考

  • [2]. Shaw MA, et, al. Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide. Biochemistry. 2003 May 27;42(20):6128-35.
  • Cheung, A., et al.: Nat. Cell Biol., 4, 83 (2002),
  • [1]. Cheung A, et al. A small-molecule inhibitor of skeletal muscle myosin II. Nat Cell Biol. 2002 Jan;4(1):83-8.
  • [1]. Cheung A, et al. A small-molecule inhibitor of skeletal muscle myosin II. Nat Cell Biol. 2002 Jan;4(1):83-8.
  • [2]. Shaw MA, et, al. Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide. Biochemistry. 2003 May 27;42(20):6128-35.

安全信息

RTECSXT5490000
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition Light Sensitive 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCNSA6 National Academy of Sciences, National Research Council,
   Chemical-Biological Coordination Center, Review.  (Washington, DC)
   Volume(issue)/page/year: 5,41,1953

Hazard statements
  • H301 Toxic if swallowed 吞食有毒
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P310
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

其他信息

  • 图谱信息:N-苄基-对甲苯磺酸胺(1576-37-0)质谱(MS) N-苄基-对甲苯磺酸胺(1576-37-0)红外图谱(IR2) N-苄基-对甲苯磺酸胺(1576-37-0)红外图谱(IR1)
  • TCI Shanghai:N-苄基-对甲苯磺酰胺 N-Benzyl-p-toluenesulfonamide,>;98.0%(N)(1576-37-0)
  • MOL 文件:1576-37-0.mol
  • N-苄基-对甲苯磺酸胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 B3082 N-苄基-对甲苯磺酰胺 N-Benzyl-p-toluenesulfonamide 5G 968元 2014/06/02 B3082 N-苄基-对甲苯磺酰胺 N-Benzyl-p-toluenesulfonamide 25G 2910元
  • Sigma Aldrich:1576-37-0(sigmaaldrich)

系列性分类

  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Myosin  (肌球蛋白)

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