(R)-(+)-Thalidomide (R)-(+)-沙利度胺
CAS 2614-06-4 MFCD00210220
化学结构图
SMILES: O=C1CC[C@@H](N2C(=O)c3ccccc3C2=O)C(=O)N1
化学属性
| Mol. Formula | C13H10N2O4 |
|---|---|
| Mol. Weight | 258.25 |
别名和识别编码
| Chemical Name | (R)-(+)-Thalidomide |
|---|---|
| CAS Number | 2614-06-4 |
| Synonym | R-(+)-Thalidomide (+)-Thalidomide (R)-Thalidomide 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-, (R)- NSC 91729 (R)-(+)-2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione |
| MDL Number | MFCD00210220 |
| PubChem Substance ID | 75792 |
| Chemical Name Translation | (R)-(+)-沙利度胺 |
| InChIKey | UEJJHQNACJXSKW-SECBINFHSA-N |
| Wiswesser Line Notation | T56 BVNVJ C- DT6VMVTJ |
| InChI | InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)/t9-/m1/s1 |
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分类
- Chiral Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals,
- {SNA} Angiogenesis Regulators, Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Celgene, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, ECM Related Proteins and Peptides, Enzymes, Inhibitors, and Substrates, Extracellular Matrix, Matrix Metalloproteinases Products, T
产品应用
- Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative.
相关文献及参考
- D?Amato, r.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 4082 (1994),
- Makonkawkeyoon, S., et al.: Proc. Natl. Acad. Sci. USA, 90, 5974 (1993),
安全信息
GHS Symbol
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- H302 Harmful if swallowed 吞食有害
- P308+P313
- P201 Obtain special instructions before use. 使用前获取专门指示。
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 215,296,1967
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 50 mg/kg SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 29,1640,1979
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE : 900 mg/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 215,296,1967
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