Roxithromycin 罗红霉素

CAS 80214-83-1 MFCD00214389

化学结构图

80214-83-1
SMILES: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)/C(=N/OCOCCOC)/[C@H](C)[C@@H](O)[C@]1(C)O

化学属性

Mol. FormulaC41H76N2O15
Mol. Weight837
Melting Point111-118

别名和识别编码

Chemical NameRoxithromycin
CAS Number80214-83-1
Synonym Roxithromycin Rotramin Forilin Overal Surli Roxithromycin A Rossitrol Claramid Rulid Brilid Erythromycin 9-(-O-[2-methoxyethoxy]methyloxime) RU 965 RU 28965 Roxid (9E)-9-[O-[(2-Methoxyethoxy)methyl]oxime] Erythromycin Assoral Roxeptin
MDL NumberMFCD00214389
PubChem Substance ID24899369
Chemical Name Translation罗红霉素
Beilstein Registry Number4286925
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分类

  • Pharmaceuticals
  • Chiral Reagents
  • {SNA} Antibacterial, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Chemical Structure Class, Interferes with Protein Synthesis, L - Z, Macrolides, Mechanism of Action, Spectrum of Activity, 抗生素, 生化试剂
  • Intermediates & Fine Chemicals,
  • {SNA} 1694 Pharmaceuticals & Personal Care Products, Method and Regulation Specific, Analytical Standards, Analytical/Chromatography, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,

产品应用

  • Semisynthetic Erythromycin derivative. Antibacterial.

相关文献及参考

  • Jones, R.N., et al.: Antimicrob. Agents Chemother., 24, 209 (1983),
  • Barry, A.L., et al.: Eur. J. Clin. Microbiol., 5, 536 (1986),
  • Grassi, C., et al.: Chemioterapia, 6, 41 (1987),

安全信息

WGK Germany3
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSKF4990000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn
Risk Statements
Safety Statements
Precautionary statements 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : .2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,1471,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 665 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,1471,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 830 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - other changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   36(Suppl 4),94,1988

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics N-S - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics N-S - Antibiotics A to Z
  1. Functional Group 官能团索引
  2. oxime ether

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