(5-Chlorothiophen-2-yl)boronic acid 2-氯噻吩-5-硼酸

CAS 162607-18-3 MFCD00236030

化学结构图

162607-18-3
SMILES: OB(O)c1ccc(Cl)s1

化学属性

Mol. FormulaC4
Mol. Weight162
Melting Pointca 136-140°
TSCANo

别名和识别编码

Chemical Name(5-Chlorothiophen-2-yl)boronic acid
CAS Number162607-18-3
Alfabeta NameCHLOROTHIOPHENEBORONICACID 52---
MDL NumberMFCD00236030
Synonym (5-Chlorothiophen-2-yl)boronic acid 5-氯噻吩-2-硼酸 (5-Chlorothiophen-2-yl)boronic acid 5-Chloro-2-thienylboronic acid 5-氯-2-噻吩硼酸 5-氯噻吩-2-硼酸
PubChem Substance ID2734324
Reaxys-RN8478804
Beilstein Registry Number8478804
Chemical Name Translation2-氯噻吩-5-硼酸
LabNetwork Molecule IDLN00112197
InChIInChI=1S/C4H4BClO2S/c6-4-2-1-3(9-4)5(7)8/h1-2,7-8H
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分类

  • {SNA} Boronic Acids, Boronic Acids and Derivatives, Chemical Synthesis, Heteroaryl Boronic Acids, Organometallic Reagents
  • {SA} Boronic Acids, Boronic Acids and Derivatives, Chemical Synthesis, Heteroaryl Boronic Acids, Organometallic Reagents

相关文献及参考

  • 1. Fairlamb, I. J. S.; et al., Suzuki-Miyaura cross-couplings mediated by trans-PdBr(N-Succ)(PPh3)2: a convenient synthetic method for diarylmethanes and aryl(heteroaryl)methanes Synthesis , 508-510, (2009)
  • 2. Huang, X.; et al., Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors ACS Med. Chem. Lett. 2 , 632-637, (2011)
  • 3. Guerrero, M.; et al., Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4(S1P4) receptor antagonists Bioorg. Med. Chem. Lett. 21 , 3632-3636, (2011)
  • 4. Hille, U. E.; et al., Optimization of the First Selective Steroid-11ß-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases ACS Med. Chem. Lett. 2 , 559-564, (2011)

安全信息

Warnings IRRITANT
WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Signal word
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P302+P352+P332+P313+P362+P364
  • P332+P313
  • P305+P351+P338+P337+P313
  • P302+P350
  • P337+P313
  • P305+P351+P338
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S37 Wear suitable gloves 戴适当手套;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
GHS Symbol

系列性分类