Benfotiamine 苯磷硫胺

CAS 22457-89-2 MFCD00057343

化学结构图

22457-89-2
SMILES: C/C(=C(/CCOP(O)(O)=O)\SC(=O)C1C=CC=CC=1)/N(CC1=CN=C(C)N=C1N)C=O

化学属性

Mol. FormulaC19H23N4O6PS
Mol. Weight466

别名和识别编码

Chemical NameBenfotiamine
Synonym Benfotiamine
MDL NumberMFCD00057343
PubChem Substance ID253662524
CAS Number22457-89-2
EC Number245-013-4
Reaxys-RN771326
Chemical Name Translation苯磷硫胺
Merck Number1041
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分类

  • Nutrition Research, Vitamin B, Vitamin B1, Vitamins
  • {SNA} Vitamin B, Vitamin B1, Vitamins, 细胞生物学, 营养研究
  • {SNA} Nutrition Research, Vitamin B, Vitamin B1, Vitamins
  • {SNA} Vitamin B, Vitamin B1, Vitamins, 生化试剂

相关文献及参考

  • WADA T, TAKAGI H, MINAKAMI H, et al., A new thiamine derivative, S-benzoylthiamine O-monophosphate. Science 134 , 195-196, (1961) 摘要
  • Ziems M, Netzel M, Bitsch I., Biokinetic parameters and metabolism of S-benzoylthiamine-O-monophosphate. Biofactors 11 , 109-110, (2000) 摘要
  • Volvert ML, Seyen S, Piette M, et al., Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives. BMC Pharmacol. 8 , 10, (2008) 摘要
  • Balakumar P, Rohilla A, et al., The multifaceted therapeutic potential of benfotiamine. Pharmacol. Res. 61 , 482-488, (2010) 摘要
  • Yadav UC, Kalariya NM, et al., Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages. Free Radic. Biol. Med. 48 , 1423-1434, (2010) 摘要
  • Du Y, Kowluru A, Kern TS., PP2A contributes to endothelial death in high glucose: inhibition by benfotiamine. Am. J. Physiol. Regul. Integr. Comp. Physiol. 299 , R1610-R1617, (2010) 摘要
  • Kihm LP, Müller-Krebs S, Klein J, et al., Benfotiamine protects against peritoneal and kidney damage in peritoneal dialysis. J. Am. Soc. Nephrol. 22 , 914-926, (2011) 摘要
  • Merck 14 ,1041

安全信息

WGK Germany2
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSDH6910000
Storage condition 0-10°C

系列性分类


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