9-Methyl-3-((2-Methyl-1H-Imidazol-1-Yl)Methyl)-1,2,3,9-Tetrahydro-4H-Carbazol-4-One Hydrochloride Dihydrate 9-甲基-3-((2-甲基-1H-咪唑-1-基)甲基)-2,3-二氢-1H-咔唑-4(9H)-酮盐酸盐二水合物
CAS 103639-04-9 MFCD00374371
化学结构图
SMILES: O.O.Cl.CN1C2C=CC=CC=2C2=C1CCC(CN1C=CN=C1C)C2=O
化学属性
| Mol. Formula | C18H24ClN3O3 |
|---|---|
| Mol. Weight | 366 |
| Melting Point | 176.0 to 180.0 deg-C |
别名和识别编码
| Chemical Name | 9-Methyl-3-((2-Methyl-1H-Imidazol-1-Yl)Methyl)-1,2,3,9-Tetrahydro-4H-Carbazol-4-One Hydrochloride Dihydrate |
|---|---|
| Synonym | 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride GR 38032F Ondansetron Hydrochloride Ondansetron hydrochloride dihydrate |
| MDL Number | MFCD00374371 |
| CAS Number | 103639-04-9 |
| Reaxys-RN | 7403248 |
| PubChem Substance ID | 172089079 |
| Chemical Name Translation | 9-甲基-3-((2-甲基-1H-咪唑-1-基)甲基)-2,3-二氢-1H-咔唑-4(9H)-酮盐酸盐二水合物 |
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分类
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, GlaxoSmithKline, Neuroscience, Neurotransmission, Neurotransmitters, O, Serotonergics
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards
相关文献及参考
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- [3]. Wildeboer KM, et al. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009 Dec 1;1300:41-50.
- [4]. Khedhaier A, et al. Circadian rhythms in toxic effects of the serotonin antagonist ondansetron in mice. Chronobiol Int. 2003 Nov;20(6):1103-16.
- [5]. Umathe SN, et al. The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice. Behav Pharmacol. 2009 Feb;20(1):78-83.
- [6]. Doggrell SA, et al. Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia. Expert Opin Drug Saf. 2013 May;12(3):421-31.
- [1]. Brown AM, et al. Ion permeation an
安全信息
GHS Symbol
- P301+P310+P330
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P405 Store locked up. 上锁保管。
- P301+P310
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- H318 Causes serious eye damage 严重伤害眼睛
- H301 Toxic if swallowed 吞食有毒
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S39 Wear eye/face protection 戴眼睛/面孔保护装置；
- R25 Toxic if swallowed 吞咽有毒
- R50/53
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
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