1-Methyl-L-tryptophan 1-甲基-L-色氨酸

CAS 21339-55-9 MFCD00467133

化学结构图

21339-55-9
SMILES: Cn1cc(C[C@H](N)C(=O)O)c2ccccc21

化学属性

Mol. FormulaC12H14N2O2
Mol. Weight218.25
Melting Point242-245 °C(lit.)
Density1.28
Danger-Level-
pH-:-
Redox-

别名和识别编码

Chemical NameH-Trp(1-Me)-OH
MDL NumberMFCD00467133
PubChem Substance ID24868339
Synonym 1-Methyltryptophan; L-(-)-1-Methyltryptophan; L-1-Methyltryptophan 1-甲基-L-色氨酸 1-Methyltryptophan
CAS Number21339-55-9
Chemical Name Translation1-甲基-L-色氨酸
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分类

  • {SNA} Amino Acid Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Tryptophan
  • {SNA} Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Tryptophan

相关文献及参考

  • [2]. Liu X, et, al. 1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells. Int J Cancer. 2018 Sep 15;143(6):1516-1529.
  • [1]. Huang GL, et, al. PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase. Nanomaterials (Basel). 2019 May 9;9(5):719.
  • [1]. Huang GL, et, al. PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase. Nanomaterials (Basel). 2019 May 9;9(5):719.
  • [2]. Liu X, et, al. 1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells. Int J Cancer. 2018 Sep 15;143(6):1516-1529.

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSYN7135000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 286 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 1,515,1976

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