Estrone 3-O-Sulfamate

CAS 148672-09-7 MFCD00676965

化学结构图

148672-09-7
SMILES: C[C@@]12CC[C@@H]3[C@H](CCC4=CC(=CC=C43)OS(N)(=O)=O)[C@H]1CCC2=O |&1:1,4,5,19|

化学属性

Mol. Weight349.44
Mol. FormulaC18H23NO4S

别名和识别编码

CAS Number148672-09-7
Chemical NameEstrone sulfamate
Synonym 1,3,5(10)-Estratrien-17-one 3-sulfamate 3-[(Aminosulfonyl)oxy]estra-1,3,5(10)-trien-17-one EMATE Estrone 3-Sulfamate Estrone O-Sulfamate Estrone Sulfamate
MDL NumberMFCD00676965
Chemical Name Translation
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Biochemicals and Reagents, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Estrone sulfatase
  • {SNA} Biochemicals and Reagents, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Estrone sulfatase
  • {SNA} D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Estrone sulfatase, 生化试剂, 酶、抑制剂和底物

产品应用

  • A potent inhibitor of estrone sulfatase. Inhibits estrone sulfatase >99% at 0.1uM in intact MCF-7 cells, IC50=65pM.

相关文献及参考

  • Woo, L.W., et al.: J. Med. Chem., 41, 1068 (1998)
  • 1. Nussbaumer, P., et al., 2-Substituted 4-(thio)chromenone 6-O-sulfamates: potent inhibitors of human steroid sulfatase J. Med. Chem. 45 , 4310-4320, (2002)
  • Purohit, A., et al. Biochemistry 34 , 11508, (1995) 摘要
  • Woo, L.W.L., et al. J. Med. Chem. 39 , 1349, (1996) 摘要

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. D to K - Enzyme Inhibitors by Enzyme
  7. Estrone sulfatase - D to K

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