Anhydrous Docetaxel 多烯紫杉醇
CAS 114977-28-5 MFCD00800737
化学结构图
SMILES: CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C
化学属性
| Mol. Formula | C43H53NO14 |
|---|---|
| Mol. Weight | 807.97 |
| Melting Point | 170-173 |
| Density | 1.38 |
| Boiling Point | 900.5 |
别名和识别编码
| Chemical Name | Anhydrous Docetaxel |
|---|---|
| CAS Number | 114977-28-5 |
| Alfabeta Name | DOCETAXEL |
| MDL Number | MFCD00800737 |
| Synonym | Docetaxol Docetaxel RP 56976 Taxotere 多西他赛 多烯紫杉醇 |
| PubChem Substance ID | 160871242 |
| Chemical Name Translation | 多烯紫杉醇 |
| Reaxys-RN | 4290183 |
| Merck Number | 3397 |
| Beilstein Registry Number | 4290183 |
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分类
- {SNA} Antibiotics, Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience, Other Apoptosis Related Reagents
产品应用
- 多西紫杉醇可用于研究抗生素，细胞生物学，细胞信号传导，神经科学,细胞凋亡和细胞周期。多西紫杉醇也用于研究多西紫杉醇化疗引起的脱发，预防以及治疗禁忌标准化疗患者的非小细胞肺癌。多西紫杉醇也被用来研究缺氧诱导因子-1α和2α在雄激素不敏感的前列腺癌细胞的作用。
相关文献及参考
- [2]. Che CL, et al. DNA microarray reveals different pathways responding to NSC 125973 and docetaxel in non-small cell lung cancer cell line. Int J Clin Exp Pathol. 2013 Jul 15;6(8):1538-48.
- [3]. Obi-Ioka Y, et al. Involvement of Wee1 in the circadian rhythm dependent intestinal damage induced by docetaxel. J Pharmacol Exp Ther. 2013 Oct;347(1):242-8.
- [4]. Li C, et al. Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. J Pharm Biomed Anal. 2016 Sep 5;128:286-93.
- Merck: 14,3397
- [1]. Attia RT, et al. The chemomodulatory effects of glufosfamide on docetaxel cytotoxicity in prostate cancer cells. PeerJ. 2016 Jun 29;4:e2168.
- [1]. Attia RT, et al. The chemomodulatory effects of glufosfamide on docetaxel cytotoxicity in prostate cancer cells. PeerJ. 2016 Jun 29;4:e2168.
- [2]. Che CL, et al. DNA microarray reveals different pathways responding to NSC 125973 and docetaxel in non
安全信息
GHS Symbol
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P405 Store locked up. 上锁保管。
- P308+P313
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 2500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SOLGAV Seminars in Oncology. (Grune & Stratton Inc., Journal Subscription Dept., POB 6280, Duluth, MN 55806) V.1- 1974- Volume(issue)/page/year: 22(Suppl 4),3,1995
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 156 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SOLGAV Seminars in Oncology. (Grune & Stratton Inc., Journal Subscription Dept., POB 6280, Duluth, MN 55806) V.1- 1974- Volume(issue)/page/year: 22(Suppl 4),3,1995
其他信息
- Docetaxel(Taxotere), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.
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