Dorzolamide

CAS 120279-96-1 MFCD00865636

化学结构图

120279-96-1
SMILES: C[C@H]1C[C@H](NCC)C2C=C(SC=2S1(=O)=O)S(N)(=O)=O

化学属性

Mol. FormulaC10H16N2O4S3
Mol. Weight324.44

别名和识别编码

Chemical NameDorzolamide
Synonym (4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide (4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide 4S,6S-Dorzolamide L-671,152 MK-507 4S,6S-Dorzolamide Dorzolamide L-671,152 MK-507
MDL NumberMFCD00865636
Chemical Name Translation
PubChem Substance ID329824746
CAS Number120279-96-1
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分类

  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Cell Stress, New Products, Nitric Oxide and Cell Stress, Oxidative Stress Proteins and Reagents
  • {SNA} Bioactive Small Molecule Alphabetical Index, DIG-DY, 一氧化氮和细胞应激, 氧化应激蛋白和试剂, 生物活性小分子, 细胞信号转导和神经科学,

相关文献及参考

  • [2]. Sangly P Srinivas, et al. Inhibition of carbonic anhydrase activity in cultured bovine corneal endothelial cells by dorzolamide. Invest Ophthalmol Vis Sci. 2002 Oct;43(10):3273-8.
  • [3]. Belal M Ali, et al. Dorzolamide synergizes the antitumor activity of mitomycin C against Ehrlich's carcinoma grown in mice: role of thioredoxin-interacting protein. Naunyn Schmiedebergs Arch Pharmacol. 2015 Dec;388(12):1271-82.
  • [1]. J Biollaz, et al. Whole-blood pharmacokinetics and metabolic effects of the topical carbonic anhydrase inhibitor dorzolamide. Eur J Clin Pharmacol. 1995;47(5):455-60.
  • [1]. J Biollaz, et al. Whole-blood pharmacokinetics and metabolic effects of the topical carbonic anhydrase inhibitor dorzolamide. Eur J Clin Pharmacol. 1995;47(5):455-60.
  • [2]. Sangly P Srinivas, et al. Inhibition of carbonic anhydrase activity in cultured bovine corneal endothelial cells by dorzolamide. Invest Ophthalmol Vis Sci. 2002 Oct;43(10):3273-8.
  • [3]

安全信息

Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
RTECSXJ9095169
WGK Germany3
Signal word Warning
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Nitric Oxide and Cell Stress - Cell Signaling and Neuroscience
  5. Cell Stress - Nitric Oxide and Cell Stress
  6. Oxidative Stress Proteins and Reagents - Cell Stress
  1. Medical Research Areas
  2. Metabolism
  3. Carbonic Anhydrase  (碳酸酐酶)

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