Calcifediol 降钙素二醇

CAS 19356-17-3 MFCD00867077

化学结构图

19356-17-3
SMILES: [3H]C([3H])([3H])C(O)(CCC[C@@H](C)C1CC[C@H]2/C(/CCC[C@]12C)=C/C=C1/C[C@@H](O)CCC/1=C)C([3H])([3H])[3H]

化学属性

Mol. FormulaC27H44O2
Mol. Weight401
Melting Point109-111

别名和识别编码

Chemical NameCalcifediol
Synonym 25-Hydroxycholecalciferol solution 25-Hydroxyvitamin D3 25-Hydroxyvitamin D3, 25-Hydroxycholecalciferol, (3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3,25-diol
MDL NumberMFCD00867077
PubChem Substance ID329765367
EC Number242-990-9
Beilstein Registry Number4270041
CAS Number19356-17-3
Chemical Name Translation降钙素二醇
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分类

  • {SNA} Gene Regulation, Gene Regulation and Expression, Vitamin D, Vitamins, 生化试剂, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Alphabetical Listings, G-H, Stable Isotopes, Vitamins
  • {SNA} Alphabetical Listings, Bioactive Compounds, G-H,

相关文献及参考

  • [2]. Wei Zheng, et al. Vitamin D-induced vitamin D receptor expression induces tamoxifen sensitivity in MCF-7 stem cells via suppression of Wnt/β-catenin signaling. Biosci Rep. 2018 Dec 7;38(6):BSR20180595.
  • [1]. Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22.
  • [1]. Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22.
  • [2]. Wei Zheng, et al. Vitamin D-induced vitamin D receptor expression induces tamoxifen sensitivity in MCF-7 stem cells via suppression of Wnt/β-catenin signaling. Biosci Rep. 2018 Dec 7;38(6):BSR20180595.

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P302+P350
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H301+H311
  • H330 Fatal if inhaled 吸入致命
  • H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S7 Keep container tightly closed 保存在严格密闭容器中；
Hazard Codes 6.1 F T+
Risk Statements
  • R24/25 Toxic in contact with skin and if swallowed 皮肤接触及吞食都有毒
  • R26 Very toxic by inhalation 吸入极毒
  • R48/25
Packing GroupII
UN Number 2811

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Gene Regulation and Expression - Cell Signaling and Neuroscience
  5. Gene Regulation - Gene Regulation and Expression
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. H - Bioactive Small Molecules
  1. Analytical & Chromatography 分析化学与色谱
  2. Stable Isotopes 稳定同位素
  3. Alphabetical Listings for Stable Isotope Labeled Products
  4. G-H - Alphabetical Listings
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Vitamins - Nutrition Research
  4. Vitamin D - Vitamins
  5. Vitamin D3 - Vitamin D
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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