Nelfinavir Mesylate 甲磺酸奈非那韦

CAS 159989-65-8 MFCD00931436

化学结构图

159989-65-8
SMILES: CC1C(=CC=CC=1O)C(=O)N[C@@H](CSC1=CC=CC=C1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C.CS(O)(=O)=O

化学属性

Mol. FormulaC32H45N3O4S · CH3SO3H · xH2O
Mol. Weight663.89 (anhydrous basis)

别名和识别编码

Chemical NameNelfinavir Mesylate
Synonym Nelfinavir mesylate hydrate 3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate AG-1343 Nelfinavir methanesulfonate hydrate
MDL NumberMFCD00931436
Chemical Name Translation甲磺酸奈非那韦
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分类

  • {SNA} AIDS and Viral Research Reagents, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Immune Cell Signaling and Blood, Immune System Regulation, N, Pfizer Compounds, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} AIDS and Viral Research Reagents, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling and Blood, Immune System Regulation, N, Pfizer Compounds

相关文献及参考

  • [2]. Gills JJ, et al. Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that inducesendoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo. Clin Cancer Res. 2007 Sep 1;13(17):5183-94.
  • [3]. Kaldor SW, et al. Nelfinavir mesylate (AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease. J Med Chem. 1997 Nov 21;40(24):3979-85.
  • [4]. Bono C, et al. The human immunodeficiency virus-1 protease inhibitor nelfinavir impairs proteasome activity and inhibits the proliferation of multiple myeloma cells in vitro and in vivo. Haematologica. 2012;97(7):1101‐1109.
  • [5]. Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.
  • [1]. Mondal D, et al. Nelfinavir suppresses signaling and nitric oxide production by human aortic endothelial cells: protective effe

安全信息

Hazard statements
  • H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
WGK Germany3

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. Pfizer Compounds - Approved Therapeutics/Drug Candidates
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Immune Cell Signaling and Blood - Cell Signaling and Neuroscience
  5. Immune System Regulation - Immune Cell Signaling and Blood
  6. AIDS and Viral Research Reagents - Immune System Regulation
  1. Medical Research Areas
  2. Metabolism
  3. HIV Protease  (HIV蛋白酶)

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