Oligomycin 寡霉素

CAS 1404-19-9 MFCD01779388

化学结构图

1404-19-9
SMILES: CCC1C=CC=CCC(C)C(O)C(C)(O)C(=O)C(C)C(O)C(C)C(=O)C(C)C(O)C(C)C=CC(=O)OC2C(C)C(CC1)OC1(CCC(C)C(CC(C)O)O1)C2C

化学属性

Mol. Weight1.01
Mol. FormulaC45H74O11
Melting Point150

别名和识别编码

MDL NumberMFCD01779388
CAS Number1404-19-9
Beilstein Registry Number7615308
PubChem Substance ID78358496
Chemical NameOligomycin
Synonym Oligomycin from Streptomyces diastatochromogenes
Chemical Name Translation寡霉素
InChIKeyMNULEGDCPYONBU-DJRUDOHVSA-N
LabNetwork Molecule IDLN01324743
InChIInChI=1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15-,21-18+/t25-,26+,27+,28?,29?,30-,31?,32-,33-,34+,35+,36-,38-,40+,41?,42-,44+,45-/m1/s1
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分类

  • {SNA} Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antifungal, Antineoplastic and Immunosuppressive Antibiotics, Biochem
  • {SNA} Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antifungal, Antineoplastic and Immunosuppressive Antibiotics, Bioactive Small Molecule Alphabetical Index, Chemical Structure Class, Inhibits an Enzyme, Macrolides, Mechanism of Action, O, Spectrum of Activity, 一氧化氮和细胞应激, 抗生素, 生化试剂, 生物活性小分子, 线粒体抑制剂, 细胞信号转导和神经科学,

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P301+P310
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
Signal word Danger
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
RTECSRK3325000 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ANTCAO Antibiotics and Chemotherapy (Washington, DC).  (Washington, DC)
   V.1-12, 1951-62.  For publisher information, see CLMEA3.
   Volume(issue)/page/year: 4,962,1954

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AGACBH Agents and Actions, A Swiss Journal of Pharmacology.  (Birkhaeuser
   Verlag, POB 133, CH-4010 Basel, Switzerland)  V.1-    1969/70-
   Volume(issue)/page/year: 15,660,1984

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 ug/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   ANTCAO Antibiotics and Chemotherapy (Washington, DC).  (Washington, DC)
   V.1-12, 1951-62.  For publisher information, see CLMEA3.
   Volume(issue)/page/year: 4,962,1954

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics N-S - Antibiotics A to Z
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Antibiotics by Application
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Mechanism of Action
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Chemical Structure Class
  5. Indol Derivatives
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Spectrum of Activity
  5. Antibacterial
  6. L - Z
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Nitric Oxide and Cell Stress
  5. Cell Stress
  6. Antioxidants and Cytoprotectants

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