6-[3-(1-三环[3.3.1.13.7]癸烷)-4-甲氧基-苯基]萘-2-甲酸 6-[3-(1-金刚烷基)-4-甲氧苯基]-2-萘甲酸

CAS 106685-40-9 MFCD03106112

化学结构图

106685-40-9
SMILES: COC1=CC=C(C=C1[C@@]12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C1=CC2=CC=C(C=C2C=C1)C(O)=O |&1:8,10,12,15|

化学属性

Mol. FormulaC28H28O3
Mol. Weight412.53

别名和识别编码

Chemical Name6-[3-(1-三环[3.3.1.13.7]癸烷)-4-甲氧基-苯基]萘-2-甲酸
CAS Number106685-40-9
Alfabeta NameADAMANTANYLMETHOXYPHENYLNAPHTHOICACID 63142(())--------
MDL NumberMFCD03106112
Synonym Adapalene 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid CD-271 Differin 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic Acid
Chemical Name Translation6-[3-(1-金刚烷基)-4-甲氧苯基]-2-萘甲酸
Reaxys-RN7393980
Merck Number150
PubChem Substance ID172088913
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分类

  • Pharmaceuticals
  • {SNA} A-AM, Bioactive Small Molecule Alphabetical Index, Gene Regulation and Expression, PPAR and RXR Regulators, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} A-AM, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression, PPAR and RXR Regulators
  • Aromatics
  • Intermediates & Fine Chemicals,

产品应用

  • Retinoid selective for retinoic acid receptor (RAR) subtypes ? and ?. Antiacne.

相关文献及参考

  • [2]. Wang Q, et, al. Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1. Bioorg Chem. 2019 Dec;93:103315.
  • [3]. Shi XN, et, al. Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma. Mol Med Rep. 2015 Nov;12(5):6501-8.
  • Bernard, B.A., et al.: Skin Pharmacol., 6, 61 (1993),
  • Griffiths, C.E.M., et al.: J. Invest. Dermatol., 101, 325 (1993),
  • Waugh, J., et al.: Drugs, 64, 1465 (2004),
  • [1]. Shroot B, et, al. Pharmacology and chemistry of adapalene. J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S96-103.
  • [1]. Shroot B, et, al. Pharmacology and chemistry of adapalene. J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S96-103.
  • [2]. Wang Q, et, al. Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1. Bioorg Chem. 2019 Dec;93:103315.
  • [3]. Shi XN, et, al. Adapalene inhibits the activity of cyclin-dependent kinase 2 in

安全信息

Warnings IRRITANT
WGK Germanynwg
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
RTECSQJ1987000
GHS Symbol
Signal word
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P308+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Storage condition 0-10°C

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Gene Regulation and Expression - Cell Signaling and Neuroscience
  5. PPAR and RXR Regulators - Gene Regulation and Expression
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. A-AM - Bioactive Small Molecules
  1. Medical Research Areas
  2. Metabolism
  3. RAR/RXR  (维甲酸受体)

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