Ximelagatran

CAS 192939-46-1 MFCD05861056

化学结构图

192939-46-1
SMILES: CCOC(=O)CN[C@H](C1CCCCC1)C(=O)N1CC[C@H]1C(=O)NCC1C=CC(=CC=1)C(=N)NO

化学属性

Mol. FormulaC24H35N5O5
Mol. Weight473.57

别名和识别编码

Chemical NameXimelagatran
CAS Number192939-46-1
Synonym N-[(1R)-1-Cyclohexyl-2-[(2S)-2-[[[[4-[(hydroxyamino)iminomethyl]phenyl]methyl]amino]carbonyl]-1-azetidinyl]-2-oxoethyl]glycine Ethyl Ester Exanta H 376/95
Chemical Name Translation
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Aromatics
  • Chiral Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • An orally active direct thrombin inhibitor; prodrug of Melagatran. Antithrombotic.

相关文献及参考

  • [2]. Gao JH, et al. Effects of different anticoagulant drugs on the prevention of complications in patients after arthroplasty: A network meta-analysis. Medicine (Baltimore). 2017 Oct;96(40):e8059.
  • [3]. Francis CW, et al. Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacement. N Engl J Med. 2003 Oct 30;349(18):1703-12.
  • Boos, C.J., et al.: Eur. J. Int. Med., 16, 267 (2005),
  • Kalus, J.S., et al.: Expert Opin. Invest. Drugs, 13, 465 (2004),
  • Owens, P.K., et al.: J. Pharm. Biomed. Anal., 27, 587 (2002),
  • [1]. Colwell CW Jr, et al. Comparison of ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the preventi
  • [1]. Colwell CW Jr, et al. Comparison of ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the prevention of venous thromboembolism following total hip replacement. A randomized, double-blind study. J Thromb Haemost. 2003 Oct;1(10):2119-30.

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Thrombin  (凝血酶)

相关产品推荐