Tolterodine
CAS 124937-51-5 MFCD07771985
化学结构图
SMILES: Cc1ccc(O)c([C@H](CCN(C(C)C)C(C)C)c2ccccc2)c1
化学属性
| Mol. Formula | C22H31NO·C4H6O6 |
|---|---|
| Mol. Weight | 475.57 |
别名和识别编码
| Chemical Name | Tolterodine L-tartrate |
|---|---|
| Synonym | 2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl-phenol tartrate 2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl-phenol tartrate Detrusitol PNU-200583E Detrol Detrol LA Detrusitol PHA 686464B PHA-686464B PHA686464B PNU-200583E Tartrate, Tolterodine Tolterodine L-tartrate Unidet Urotrol tolterodine tolterodine tartrate |
| MDL Number | MFCD07771985 |
| Chemical Name Translation | |
| PubChem Substance ID | 443879 |
| CAS Number | 124937-51-5 (free base) |
| LabNetwork Molecule ID | LN01312349 |
| InChI | InChI=1S/C22H31NO/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24/h6-12,15-17,20,24H,13-14H2,1-5H3/t20-/m1/s1 |
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资金保障
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分类
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cholinergics, Fluorination Ready Pharma-Developed Compounds, Neuroscience, Neurotransmission, Neurotransmitters, Pfizer Compounds, T, 生物活性小分子, 细胞信号转导和神经科学,
相关文献及参考
- [2]. Andersson SH, et al. Biotransformation of tolterodine, a new muscarinic receptor antagonist, in mice, rats, and dogs. Drug Metab Dispos. 1998 Jun;26(6):528-35.
- [3]. Cappon GD, et al. Tolterodine does not affect memory assessed by passive-avoidance response test in mice. Eur J Pharmacol. 2008 Jan 28;579(1-3):225-8.
- [1]. Nilvebrant L. Tolterodine and its active 5-hydroxymethyl metabolite: pure muscarinic receptor antagonists. Pharmacol Toxicol. 2002 May;90(5):260-7.
- [1]. Nilvebrant L. Tolterodine and its active 5-hydroxymethyl metabolite: pure muscarinic receptor antagonists. Pharmacol Toxicol. 2002 May;90(5):260-7.
- [2]. Andersson SH, et al. Biotransformation of tolterodine, a new muscarinic receptor antagonist, in mice, rats, and dogs. Drug Metab Dispos. 1998 Jun;26(6):528-35.
- [3]. Cappon GD, et al. Tolterodine does not affect memory assessed by passive-avoidance response test in mice. Eur J Pharmacol. 2008 Jan 28;579(1-3):225-8.
安全信息
- S57 Use appropriate containment to avoid environmental contamination 使用适当容器避免环境污染；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S22 Do not breathe dust 不要吸入粉尘；
GHS Symbol
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P301+P310
- P308+P313
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P330 Rinse mouth. 漱口
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H301 Toxic if swallowed 吞食有毒
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- R51/53
- R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
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