3-(2-(((4-Carbamimidoylphenyl)Amino)Methyl)-1-Methyl-N-(Pyridin-2-Yl)-1H-Benzo[D]Imidazole-5-Carboxamido)Propanoic Acid N-[[2-[[[4-(氨咪甲基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-2-吡啶基-Β-丙氨酸

CAS 211914-51-1 MFCD09837830

化学结构图

211914-51-1
SMILES: CN1C(CNC2C=CC(=CC=2)C(N)=N)=NC2C=C(C=CC1=2)C(=O)N(CCC(O)=O)C1=CC=CC=N1

化学属性

Mol. FormulaC25H25N7O3
Mol. Weight471.51

别名和识别编码

Chemical Name3-(2-(((4-Carbamimidoylphenyl)Amino)Methyl)-1-Methyl-N-(Pyridin-2-Yl)-1H-Benzo[D]Imidazole-5-Carboxamido)Propanoic Acid
CAS Number211914-51-1
Synonym N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-?-alanine BIBR 953 BIBR 953ZW
Chemical Name TranslationN-[[2-[[[4-(氨咪甲基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-2-吡啶基-Β-丙氨酸
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分类

  • Aromatics
  • Heterocycles
  • Nucleotides
  • Bases & Related Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Nonpeptide, direct thrombin inhibitor. Antithrombotic.

相关文献及参考

  • [2]. Hauel NH, et al. Structure-based design of novel potent nonpeptide thrombin inhibitors. J Med Chem. 2002 Apr 25;45(9):1757-66.
  • [3]. Wienen W, et al. Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rats. Thromb Haemost. 2007 Aug;98(2):333-8.
  • Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002),
  • Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002),
  • Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005),
  • [1]. Wienen W, Stassen JM, Priepke H, In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally activeprodrug, dabigatran etexilate. Thromb Haemost.
  • [1]. Wienen W, Stassen JM, Priepke H, In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally activeprodrug, dabigatran etexilate. Thromb Haemost. 2007 Jul;98(1):155-62.

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Thrombin  (凝血酶)

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