SB-505124 SB-505124
CAS 694433-59-5 MFCD11045901
化学结构图
SMILES: Cc1cccc(-c2[nH]c(C(C)(C)C)nc2-c2ccc3c(c2)OCO3)n1
化学属性
| Mol. Formula | C20H21N3O2· xHCl · yH2O |
|---|---|
| Mol. Weight | 335.4 |
| Appearance | Light peach to pale pink solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | SB-505124 |
|---|---|
| Synonym | SB505124; SB-505124; SB 505124 |
| MDL Number | MFCD11045901 |
| PubChem Substance ID | 24724611 |
| Chemical Name Translation | SB-505124 |
| Formula | C20H21N3O2 |
| IUPAC Name | 2-(4-(benzo[d][1,3]dioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl)-6-methylpyridine |
| InChIKey | WGZOTBUYUFBEPZ-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H21N3O2/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15/h5-10H,11H2,1-4H3,(H,22,23) |
| Canonical SMILES | CC1=CC=CC(C2=C(C3=CC=C(OCO4)C4=C3)N=C(C(C)(C)C)N2)=N1 |
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分类
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Diversification Ready Pharma-Developed Compounds, GlaxoSmithKline, Kinase/Phosphatase Biology, Protein Kinase Inhibitors, S, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, Transforming Growth Factor-β Type I Receptor Kinase (ALK5), Tyrosine Kinase-Like Biology, Tyrosine Kinase-Like Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, GlaxoSmithKline, Kinase/Phosphatase Biology, Protein Kinase Inhibitors, S,
产品应用
- SB505124: SB505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5, ALK4 and ALK7) with potential anticancer activity. SB505124 selectively inhibits signaling from TGF-β and activin; does not inhibit other ALK family members. SB-505124 selectively and concentration-dependently inhibits ALK4-, ALK5-, and ALK 7-dependent activation of downstream cytoplasmic signal transducers, Smad2 and Smad3, and of TGF-beta-induced mitogen-activated protein kinase pathway components but does not alter ALK1, ALK2, ALK3 or ALK6-induced Smad signaling.
安全信息
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
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