5-(6-Quinoxalinylmethylene)-2,4-Thiazolidinedione 5-(6-喹喔啉亚甲基)-2,4-噻唑烷二酮

CAS 648450-29-7 MFCD11100415

化学结构图

648450-29-7
SMILES: O=C1NC(=O)/C(=C\c2ccc3nccnc3c2)S1

化学属性

Mol. FormulaC12H7N3O2S
Mol. Weight257.27
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name5-(6-Quinoxalinylmethylene)-2,4-Thiazolidinedione
Synonym 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione AS 605240; AS605240; AS-605240.
MDL NumberMFCD11100415
PubChem Substance ID329770591
Chemical Name Translation5-(6-喹喔啉亚甲基)-2,4-噻唑烷二酮
FormulaC12H7N3O2S
IUPAC Name(E)-5-(quinoxalin-6-ylmethylene)thiazolidine-2,4-dione
InChIKeySQWZFLMPDUSYGV-UXBLZVDNSA-N
InChIInChI=1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17)/b10-6+
Canonical SMILESO=C(NC/1=O)SC1=C\C2=CC=C3N=CC=NC3=C2
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分类

  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Phosphatidylinositol 3-kinase (PI3K), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
  • {SNA} AN-AZ, Bioactive Small Molecule Alphabetical Index, Kinase/Phosphatase Biology, Phosphatidylinositol 3-kinase (PI3K), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • AS605240 is a selective PI3Kgamma inhibitor, has been proved effective on several inflammatory diseases. Orally administration of AS605240 significantly prevented lung inflammation and reduced collagen deposition. AS605240 also inhibited augmented expression of TNF-alpha and IL-1beta induced by bleomycin instillation. AS605240 may be a useful in treating inflammation diseases. AS605240 may represent a promising novel agent for the future therapy of pulmonary fibrosis.

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany3
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. Phosphatidylinositol 3-kinase (PI3K) - Serine/Threonine Kinase Inhibitors
  1. Medical Research Areas
  2. Apoptosis
  3. TNF-alpha

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