(E)-2-(3-(Naphthalen-2-Yl)But-2-Enamido)Benzoic Acid (E)-2-(3-(萘-2-基)丁-2-烯酰胺)苯甲酸

CAS 321674-73-1 MFCD11112195

化学结构图

321674-73-1
SMILES: C/C(=C\C(=O)Nc1ccccc1C(=O)O)c1ccc2ccccc2c1

化学属性

Mol. FormulaC21H17NO3
Mol. Weight331.36
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name(E)-2-(3-(Naphthalen-2-Yl)But-2-Enamido)Benzoic Acid
Chemical Name Translation(E)-2-(3-(萘-2-基)丁-2-烯酰胺)苯甲酸
FormulaC21H17NO3
Synonym BIBR1532; BIBR-1532; BIBR 1532.
IUPAC Name(E)-2-(3-(naphthalen-2-yl)but-2-enamido)benzoic acid
InChIKeyPGFQXGLPJUCTOI-WYMLVPIESA-N
InChIInChI=1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+
Canonical SMILESO=C(O)C1=CC=CC=C1NC(/C=C(C2=CC=C3C=CC=CC3=C2)\C)=O
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产品应用

  • BIBR1532 is a selective telomerase inhibitor. BIBR1132 is highly selective for inhibition of telomerase, resulting in delayed growth arrest of tumor cells. Treatment of cancer cells with BIBR1532 leads to progressive telomere shortening, consecutive telomere dysfunction, and finally growth arrest after a lag period that is largely dependent on initial telomere length.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. DNA Damage
  3. Telomerase

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