2-(4-(Trifluoromethyl)Phenyl)-3,5,7,8-Tetrahydro-4H-Thiopyrano[4,3-D]Pyrimidin-4-One 2-(4-(三氟甲基)苯基)-3,5,7,8-四氢-4H-硫代吡喃并[4,3-d]嘧啶-4-酮

CAS 284028-89-3 MFCD16879017

化学结构图

284028-89-3
SMILES: O=c1[nH]c(-c2ccc(C(F)(F)F)cc2)nc2c1CSCC2

化学属性

Mol. Weight312
Mol. FormulaC14H11F3N2OS
Density1.5
Boiling Point429.3
Appearance White Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Synonym 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one XAV939 XAV939; XAV 939; XAV-939.
MDL NumberN/A
Chemical Name2-(4-(Trifluoromethyl)Phenyl)-3,5,7,8-Tetrahydro-4H-Thiopyrano[4,3-D]Pyrimidin-4-One
Chemical Name Translation2-(4-(三氟甲基)苯基)-3,5,7,8-四氢-4H-硫代吡喃并[4,3-d]嘧啶-4-酮
PubChem Substance ID354333224
LabNetwork Molecule IDLN00330175
FormulaC14H11F3N2OS
IUPAC Name2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-3H-thiopyrano[4,3-d]pyrimidin-4(5H)-one
InChIKeyKLGQSVMIPOVQAX-UHFFFAOYSA-N
InChIInChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
Canonical SMILESO=C1C(CSCC2)=C2N=C(C3=CC=C(C(F)(F)F)C=C3)N1
CAS Number284028-89-3
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, DNA-RNA Transcription Regulators, Gene Regulation and Expression, X, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators, Gene Regulation and Expression, X

产品应用

  • XAV-939 is a Tankyrase (TNKS) inhibitor with potential anticancer activity. XAV-939 antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV-939 inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyogenic development in mesoderm progenitor cells.

安全信息

WGK Germany3
Safety Statements
  • S26/45
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P310+P330
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338+P337+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H319 Causes serious eye irritation 严重刺激眼睛
Signal word Danger
Hazard Codes 6.1 T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R36 Irritating to eyes 刺激眼睛
UN Number 2811
Packing GroupIII
Hazard Class6.1
Storage condition <0°C Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Gene Regulation and Expression - Cell Signaling and Neuroscience
  5. DNA-RNA Transcription Regulators - Gene Regulation and Expression
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. X - Bioactive Small Molecules
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Wnt/beta-catenin

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