4-Methyl-3-((1-Methyl-6-(Pyridin-3-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Yl)Amino)-N-(3-(Trifluoromethyl)Phenyl)Benzamide 4-甲基-3-((1-甲基-6-(吡啶-3-基)-1H-吡唑并[3,4-d]嘧啶-4-基)氨基)-N-(3-(三氟甲基)苯基)苯甲酰胺

CAS 940310-85-0 MFCD20272929

化学结构图

940310-85-0
SMILES: Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C

化学属性

Mol. Weight503.48
Mol. FormulaC26H20F3N7O
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Synonym 4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]-benzamide NVP BHG712; NVP BHG-712; NVP BHG 712; BHG-712; BHG712; BHG 712.
MDL NumberMFCD20272929
Chemical Name4-Methyl-3-((1-Methyl-6-(Pyridin-3-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Yl)Amino)-N-(3-(Trifluoromethyl)Phenyl)Benzamide
Chemical Name Translation4-甲基-3-((1-甲基-6-(吡啶-3-基)-1H-吡唑并[3,4-d]嘧啶-4-基)氨基)-N-(3-(三氟甲基)苯基)苯甲酰胺
PubChem Substance ID354335680
FormulaC26H20F3N7O
IUPAC Name4-methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide
InChIKeyZCCPLJOKGAACRT-UHFFFAOYSA-N
InChIInChI=1S/C26H20F3N7O/c1-15-8-9-16(25(37)32-19-7-3-6-18(12-19)26(27,28)29)11-21(15)33-23-20-14-31-36(2)24(20)35-22(34-23)17-5-4-10-30-13-17/h3-14H,1-2H3,(H,32,37)(H,33,34,35)
Canonical SMILESO=C(NC1=CC=CC(C(F)(F)F)=C1)C2=CC=C(C)C(NC3=C4C(N(C)N=C4)=NC(C5=CC=CN=C5)=N3)=C2
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分类

  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors, Tyrosine Kinase (TK)
  • {SNA} Bioactive Small Molecule Alphabetical Index, Kinase/Phosphatase Biology, N, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors, Tyrosine Kinase (TK), 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • NVP-BHG712, also known as BHG-712, is a EphB4 kinase inhibitor and BCR-ABL inhibitor. NVP-BHG712, which inhibits EphB4 kinase activity in the low nanomolar range in cellular assays showed high selectivity for targeting the EphB4 kinase when profiled against other kinases in biochemical as well as in cell based assays. BHG-712 shows excellent pharmacokinetic properties and potently inhibits EphB4 autophosphorylation in tissues after oral administration.

安全信息

Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
GHS Symbol
Precautionary statements
  • P301+P310
WGK Germany3
Signal word Danger
Hazard Codes T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
Storage condition -20°C Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Receptor Tyrosine Kinase Biology - Kinase/Phosphatase Biology
  6. Receptor Tyrosine Kinase Inhibitors - Receptor Tyrosine Kinase Biology
  7. Tyrosine Kinase (TK) - Receptor Tyrosine Kinase Inhibitors
  1. Medical Research Areas
  2. Angiogenesis
  3. Bcr-Abl
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Bcr-Abl

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